{"id":"W2898873016","doi":"10.1016/j.mcn.2018.10.005","title":"Strain differences in hippocampal synaptic dysfunction in the TgCRND8 mouse model of Alzheimer's disease: Implications for improving translational capacity","year":2018,"lang":"en","type":"article","venue":"Molecular and Cellular Neuroscience","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; St. Boniface Hospital","funders":"Alzheimer Society of Manitoba; Research Manitoba","keywords":"Long-term potentiation; Neurotransmission; Excitatory postsynaptic potential; Neuroscience; Synaptic plasticity; Hippocampal formation; Hippocampus; Biology; Alzheimer's disease; Inhibitory postsynaptic potential; Internal medicine; Medicine; Disease; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002059859,0.0001037243,0.0001299379,0.0001045765,0.0001099447,0.00002343673,0.0001088843,0.0000298231,0.00000205362],"category_scores_gemma":[0.00006766348,0.00007624226,0.00005792334,0.0002210908,0.000369031,0.00008720705,0.00001683361,0.00008504192,3.744374e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001073186,"about_ca_system_score_gemma":0.0001492079,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000318826,"about_ca_topic_score_gemma":0.00001113313,"domain_scores_codex":[0.9989691,0.00006612534,0.0001759732,0.0003054265,0.000250031,0.0002333457],"domain_scores_gemma":[0.9995317,0.00003682101,0.00004201118,0.0002040094,0.00005437804,0.0001310327],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002652244,0.0007979861,0.07187372,0.00008854386,0.00008158207,0.00001960028,0.0003521471,0.0002024579,0.9199496,0.003579536,0.000002365804,0.002787242],"study_design_scores_gemma":[0.002832208,0.0009022056,0.6212494,0.00005083724,0.0004831895,0.00001203949,0.0001153119,0.2963772,0.06720844,0.01049885,0.000002603654,0.0002676391],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9728714,0.0006597243,0.02504198,0.0005710737,0.00001693378,0.0006787971,0.0001268693,0.000007912214,0.00002530295],"genre_scores_gemma":[0.9994233,0.00001050564,0.0002763217,0.0001537609,0.00001117806,0.00009308307,0.00002208598,0.000007467289,0.000002249241],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8527412,"threshold_uncertainty_score":0.3109069,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05734859484697762,"score_gpt":0.290207245360802,"score_spread":0.2328586505138244,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}