{"id":"W2898981465","doi":"10.1016/j.freeradbiomed.2019.02.010","title":"Thioredoxin system as a gatekeeper in caspase-6 activation and nuclear lamina integrity: Implications for Alzheimer's disease","year":2019,"lang":"en","type":"article","venue":"Free Radical Biology and Medicine","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Boniface Hospital; University of Manitoba; Foundation for Spinal Cord Research","funders":"Health Sciences Centre Foundation; University of Manitoba; Paralyzed Veterans of America","keywords":"Lamin; Nuclear lamina; Programmed cell death; Cell biology; Thioredoxin; Oxidative stress; Biology; Chemistry; Cancer research; Apoptosis; Biochemistry; Nuclear protein; Transcription factor; Nucleus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001328153,0.00009640542,0.0001501901,0.00004507392,0.00005643607,0.000003751208,0.00006592963,0.0001974156,0.00001996607],"category_scores_gemma":[0.0001510028,0.00007196538,0.00002100935,0.00004298751,0.0001962529,0.000004325311,0.00004472056,0.0001115423,0.000003288408],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000856933,"about_ca_system_score_gemma":0.00002294797,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005635322,"about_ca_topic_score_gemma":0.00001561486,"domain_scores_codex":[0.999391,0.00004170258,0.0001301159,0.0002783588,0.00002698124,0.000131807],"domain_scores_gemma":[0.9995921,0.00003685453,0.00003999538,0.0001981418,0.00002607891,0.0001068499],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00167438,0.00007084984,0.05492295,0.0001645363,0.0001618215,0.000003460617,0.0002195088,7.97053e-7,0.744948,0.1595805,0.007986438,0.03026678],"study_design_scores_gemma":[0.009218268,0.00413396,0.6183558,0.0003110022,0.0003386542,0.0001876625,0.001057786,0.0005406134,0.004316779,0.01759328,0.3433234,0.0006227602],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991959,0.001279402,0.0003146596,0.005113259,0.0001602417,0.0003796316,0.00002803875,0.00001462896,0.0007510994],"genre_scores_gemma":[0.9982905,0.0001384081,0.0001820638,0.0008672267,0.0002401116,0.00002228638,0.0001899472,0.00001075808,0.00005874376],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7406312,"threshold_uncertainty_score":0.2934663,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01062890258870196,"score_gpt":0.2733367573937844,"score_spread":0.2627078548050825,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}