{"id":"W2899030278","doi":"10.3747/co.25.4047","title":"Predictors of Immunotherapy-Induced Immune-Related Adverse Events","year":2018,"lang":"en","type":"article","venue":"Current Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":115,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotel Dieu Hospital; Queen's University","funders":"","keywords":"Medicine; Ipilimumab; Nivolumab; Pembrolizumab; Internal medicine; Renal cell carcinoma; Kidney cancer; Odds ratio; Adverse effect; Cancer; Lung cancer; Oncology; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003740951,0.0001781354,0.000463068,0.0001710476,0.0000661444,0.000001117736,0.0001639779,0.0002067204,0.001253726],"category_scores_gemma":[0.00004900408,0.0001492067,0.0002816607,0.0003273762,0.0002965196,0.00005547514,0.0000427934,0.0002377373,0.00008650605],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002559013,"about_ca_system_score_gemma":0.0003428913,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004145038,"about_ca_topic_score_gemma":0.0000089115,"domain_scores_codex":[0.9984522,0.0001074382,0.0006842823,0.0002509745,0.0002114366,0.0002936027],"domain_scores_gemma":[0.9989483,0.00005297024,0.0003254249,0.0003922804,0.0001998704,0.00008119596],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01008479,0.002082097,0.1217982,0.0001312005,0.001368146,0.00001277569,0.00287984,2.963552e-7,0.5124257,0.00009368307,0.002803808,0.3463195],"study_design_scores_gemma":[0.02337256,0.009614946,0.507254,0.0006373407,0.0003116229,0.0001374145,0.0004330664,0.00009392491,0.07013226,0.0001496506,0.3874646,0.000398572],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869518,0.003319192,0.00002820381,0.0003072841,0.005136546,0.0005011145,0.00001030199,0.00006871345,0.003676899],"genre_scores_gemma":[0.9982302,0.0008555736,0.00006680229,0.00009970544,0.000302231,0.00002605995,0.00003322356,0.00002637675,0.0003598975],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4422934,"threshold_uncertainty_score":0.9996592,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05266787892698031,"score_gpt":0.3754606896998456,"score_spread":0.3227928107728653,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}