{"id":"W2899033136","doi":"10.1016/j.freeradbiomed.2018.10.012","title":"Electron transport chain inhibitors alter membrane potential and induce mitochondrial fragmentation in vascular smooth muscle cells: implications for bioenergetic measurements","year":2018,"lang":"en","type":"article","venue":"Free Radical Biology and Medicine","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"","keywords":"Oligomycin; Bioenergetics; Oxidative phosphorylation; Antimycin A; Mitochondrion; Glycolysis; Fragmentation (computing); Biochemistry; Respiratory chain; Membrane potential; Rotenone; Cell biology; Chemistry; Electron transport chain; Biophysics; ATP synthase; Biology; Metabolism; ATPase; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004521779,0.0003858698,0.0004045802,0.0002778047,0.0004680507,0.0006233726,0.0006051966,0.000957453,0.003183145],"category_scores_gemma":[0.0005639857,0.0003213572,0.0004283205,0.0003902614,0.0004586178,0.001123416,0.0003437701,0.001376757,0.0002786992],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004100652,"about_ca_system_score_gemma":0.0003253273,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000914558,"about_ca_topic_score_gemma":0.001202677,"domain_scores_codex":[0.9997669,0.00004868173,0.00003047448,0.00004175851,0.00004340981,0.00006876652],"domain_scores_gemma":[0.9996099,0.0001164941,0.00009550103,0.00007550481,0.00004501471,0.00005766805],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002867216,0.0002326871,0.0006837913,0.00007417407,0.00005921438,0.0001437543,0.0001003275,0.0001185103,0.9930087,0.0004068839,0.0001260288,0.002178735],"study_design_scores_gemma":[0.0001820846,0.001375284,0.01030758,0.00001274835,0.00009966001,0.000250252,0.0002168834,0.00123812,0.9849821,0.0002888437,0.001037168,0.000009140012],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991515,0.002168476,0.00388378,0.0003782882,0.0001064093,0.00003567517,0.000347724,0.00007388712,0.001490731],"genre_scores_gemma":[0.9958999,0.0009977106,0.001407801,0.00009971266,0.00002653774,0.00003112905,0.0003777085,0.00001918189,0.001140222],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003183145,"threshold_uncertainty_score":0.01064873,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02635209949088831,"score_gpt":0.3100508967073411,"score_spread":0.2836987972164528,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}