{"id":"W2899045297","doi":"10.1097/01.hjh.0000548070.04038.1a","title":"A2921 In vivo miR-431–5p knockdown protects against angiotensin II-induced hypertension and vascular injury","year":2018,"lang":"en","type":"article","venue":"Journal of Hypertension","topic":"Nuclear Receptors and Signaling","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine; McGill University; Jewish General Hospital","funders":"","keywords":"Medicine; Gene knockdown; Angiotensin II; microRNA; Vascular smooth muscle; Oxidative stress; Pharmacology; Electrical impedance myography; Internal medicine; Endocrinology; Vasodilation; Blood pressure; Biology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002728548,0.0005433896,0.0006707451,0.0003985072,0.0003105528,0.0003675013,0.0003036034,0.0004718074,0.003088131],"category_scores_gemma":[0.0001386234,0.0002558839,0.0004720033,0.0002312913,0.0003559327,0.0002536628,0.0001689584,0.001051298,0.001028234],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002484716,"about_ca_system_score_gemma":0.0003700705,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00063607,"about_ca_topic_score_gemma":0.0008760339,"domain_scores_codex":[0.9996836,0.0000442553,0.00004148133,0.0000784095,0.00007677904,0.00007549598],"domain_scores_gemma":[0.9998003,0.00002632147,0.00005424436,0.00002264107,0.00001748632,0.00007905374],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005074384,0.0001650837,0.00006103328,0.00004097971,0.00001038606,0.00004104425,0.00001357163,0.00007062659,0.9978269,0.00006407625,0.0001722408,0.001026682],"study_design_scores_gemma":[0.0001189743,0.001924862,0.002623414,0.000007484605,0.00005557508,0.0002038525,0.00003403898,0.002188522,0.9892886,0.00007273763,0.003471514,0.00001054329],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878553,0.002125144,0.00438265,0.000354957,0.0003237106,0.000107573,0.001342909,0.0005387123,0.002969127],"genre_scores_gemma":[0.9858719,0.001470364,0.00367365,0.0001823177,0.00005365891,0.0002360571,0.00158026,0.00009544685,0.00683631],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003088131,"threshold_uncertainty_score":0.0103308,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03951141064902769,"score_gpt":0.2414309584164633,"score_spread":0.2019195477674356,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}