{"id":"W2899047681","doi":"10.1242/dev.166579","title":"Transcriptional response to Wnt activation regulates the regenerative capacity of the mammalian cochlea","year":2018,"lang":"en","type":"article","venue":"Development","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre; University of Toronto","funders":"Canadian Institutes of Health Research; National Center for Advancing Translational Sciences; University of Toronto; Hearing Health Foundation","keywords":"Biology; Wnt signaling pathway; Cochlea; Cell biology; Regenerative medicine; Regeneration (biology); Neuroscience; Stem cell; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001200179,0.0001755352,0.0001301952,0.0002179065,0.0001044705,0.0003408462,0.00009865034,0.000169972,0.0008682391],"category_scores_gemma":[0.0001432279,0.0001409116,0.0001594282,0.00009035308,0.0002149435,0.0001787246,0.0002067357,0.0002212735,0.0003767445],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002901091,"about_ca_system_score_gemma":0.0001533773,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004262901,"about_ca_topic_score_gemma":0.0007509076,"domain_scores_codex":[0.9999158,0.00001037303,0.000008715195,0.0000233508,0.00002268791,0.00001903223],"domain_scores_gemma":[0.9998862,0.00001619829,0.00003891427,0.000008818776,0.00001860788,0.00003130585],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000421718,0.000005525356,0.0009255314,0.00001047727,0.000001574862,0.0000291269,0.000008616837,0.00001761201,0.9983194,0.00005606326,0.00001270596,0.0005711716],"study_design_scores_gemma":[0.000008331027,0.0001658237,0.07314716,0.00001247381,0.00001777311,0.0004189599,0.0000594084,0.0007961001,0.9235924,0.00009780825,0.001677492,0.000006264527],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949251,0.001796408,0.001747498,0.00003833272,0.000009102466,0.000008280022,0.0003912314,0.00004451846,0.001039501],"genre_scores_gemma":[0.9957715,0.0007921533,0.001040335,0.00002890451,0.000005674878,0.00001495395,0.0005172353,0.00001484356,0.001814457],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008682391,"threshold_uncertainty_score":0.002904534,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02554259520729216,"score_gpt":0.2733628053135198,"score_spread":0.2478202101062276,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}