{"id":"W2899168417","doi":"10.3389/fnmol.2018.00394","title":"ALS Yeast Models—Past Success Stories and New Opportunities","year":2018,"lang":"nl","type":"review","venue":"Frontiers in Molecular Neuroscience","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Yeast; Amyotrophic lateral sclerosis; DECIPHER; Model organism; Biology; Neuroscience; Computational biology; Protein aggregation; Bioinformatics; Medicine; Cell biology; Genetics; Disease; Gene; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts"],"consensus_categories":[],"category_scores_codex":[0.001033978,0.000993818,0.002244355,0.0009084027,0.0003330261,0.0004879986,0.001649559,0.0005394588,0.000106156],"category_scores_gemma":[0.0005123446,0.0008758292,0.000258689,0.001440109,0.003025141,0.0007245531,0.001105592,0.001333663,0.00006532417],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004366618,"about_ca_system_score_gemma":0.001922301,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003806081,"about_ca_topic_score_gemma":0.000005577774,"domain_scores_codex":[0.9924322,0.00078266,0.001147098,0.00201265,0.001979063,0.001646355],"domain_scores_gemma":[0.9967002,0.00006017116,0.0004549625,0.001287714,0.0001941174,0.001302839],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004635846,0.0007587034,0.004046104,0.02086901,0.0003015714,0.01012627,0.001769346,0.0002739517,0.004276727,0.001768472,0.3092208,0.6461255],"study_design_scores_gemma":[0.001454523,0.001048404,0.001286327,0.01174682,0.0005153483,0.0003396714,0.0003364063,0.006523638,0.0001286496,0.0008562163,0.9741201,0.001643902],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002919751,0.9596881,0.02618068,0.001061506,0.005470167,0.002315707,0.0001579299,0.00008453529,0.002121638],"genre_scores_gemma":[0.003931475,0.9794621,0.003320264,0.001033772,0.000579502,0.00008037459,0.00005317879,0.0001645675,0.01137476],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6648993,"threshold_uncertainty_score":0.999688,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1534805843442635,"score_gpt":0.3468010247740027,"score_spread":0.1933204404297391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}