{"id":"W2899168417","doi":"10.3389/fnmol.2018.00394","title":"ALS Yeast Models—Past Success Stories and New Opportunities","year":2018,"lang":"nl","type":"review","venue":"Frontiers in Molecular Neuroscience","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Yeast; Amyotrophic lateral sclerosis; DECIPHER; Model organism; Biology; Neuroscience; Computational biology; Protein aggregation; Bioinformatics; Medicine; Cell biology; Genetics; Disease; Gene; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001843496,0.0008919865,0.001391774,0.001903638,0.0003733238,0.00139913,0.00123665,0.001364708,0.002452595],"category_scores_gemma":[0.001820022,0.0003091991,0.0004919856,0.001432849,0.001113707,0.002454977,0.001031759,0.002705633,0.001584055],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008026608,"about_ca_system_score_gemma":0.001109686,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009762122,"about_ca_topic_score_gemma":0.001617638,"domain_scores_codex":[0.9997321,0.00005789183,0.00004487301,0.00005143019,0.00008873823,0.00002489664],"domain_scores_gemma":[0.9990953,0.0004996407,0.00008126708,0.00003497367,0.0001983753,0.00009045703],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002101745,0.0000909519,0.0002698406,0.01781885,0.00008250537,0.000319084,0.0001296554,0.0003155924,0.001836465,0.01360852,0.0500057,0.9153126],"study_design_scores_gemma":[0.00001633237,0.00008249352,0.0003135324,0.002593766,0.00006571414,0.0006381125,0.00007554935,0.00004634193,0.0004440689,0.003434496,0.9922712,0.00001823746],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007239284,0.9988546,0.0000606337,0.0004636622,0.0001718003,0.000001708046,0.00001039225,0.000005959085,0.0003589041],"genre_scores_gemma":[0.0005505571,0.998587,0.0001275549,0.0002829797,0.0001842686,0.000004684611,0.00002622065,0.000002024487,0.0002348189],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002452595,"threshold_uncertainty_score":0.009749472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1534805843442635,"score_gpt":0.3468010247740027,"score_spread":0.1933204404297391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}