{"id":"W2899189284","doi":"10.1002/ejhf.1338","title":"Association with Outcomes and Response to Treatment of Trimethylamine N-Oxide in Heart Failure: Results from BIOSTAT-CHF","year":2018,"lang":"en","type":"article","venue":"European Journal of Heart Failure","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":101,"is_retracted":false,"has_abstract":true,"ca_institutions":"Surgical Specialties (Canada)","funders":"Medical Research Council; John and Lucille Van Geest Foundation; National Institute for Health and Care Research; Novo Nordisk; British Heart Foundation; NIHR Leicester Biomedical Research Centre; ResMed; Boston Scientific Corporation; Japan Heart Foundation; AstraZeneca; Servier; Amgen; University of Tokyo; European Commission; Japan Agency for Medical Research and Development","keywords":"Trimethylamine N-oxide; Medicine; Hazard ratio; Heart failure; Guideline; Internal medicine; Confidence interval; Adverse effect; Natriuretic peptide; Cardiology; Intensive care medicine; Gastroenterology; Trimethylamine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001031748,0.0001486695,0.0003214929,0.0001327942,0.00004497826,0.00002012155,0.00008191892,0.00005638071,0.000007078959],"category_scores_gemma":[0.000282132,0.0001082317,0.00007131176,0.0001204443,0.00004534548,0.000008026358,0.00003228386,0.00009524671,0.0000122457],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006148095,"about_ca_system_score_gemma":0.0001347061,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000730185,"about_ca_topic_score_gemma":0.0003234415,"domain_scores_codex":[0.9983305,0.0006092199,0.0005018146,0.0002118747,0.0001407076,0.0002059086],"domain_scores_gemma":[0.9990987,0.00008662458,0.0002752241,0.0002102763,0.0001913632,0.0001378079],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003759476,0.0001040707,0.06921593,0.000003561326,0.00007490164,0.00001882408,0.0004996785,0.000004140635,0.8996184,3.810428e-7,0.02648436,0.0002162078],"study_design_scores_gemma":[0.003983323,0.005595657,0.4769984,0.00005874666,0.00002403847,0.0000406571,0.0002049476,3.672476e-7,0.1652882,0.00000131176,0.3476959,0.0001084613],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9725595,0.0002039491,0.00003418434,0.026913,0.00005409242,0.000135242,0.00007893308,0.000002882486,0.00001828622],"genre_scores_gemma":[0.9775609,0.00003595998,0.02145348,0.0004160645,0.0001653404,4.494879e-7,0.00001711463,0.00002197722,0.0003287072],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7343303,"threshold_uncertainty_score":0.4413562,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009382447883941696,"score_gpt":0.2556875839963635,"score_spread":0.2463051361124218,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}