{"id":"W2899225691","doi":"10.3324/haematol.2018.202093","title":"Blastic plasmacytoid dendritic cell neoplasm: genomics mark epigenetic dysregulation as a primary therapeutic target","year":2018,"lang":"en","type":"article","venue":"Haematologica","topic":"Cutaneous lymphoproliferative disorders research","field":"Medicine","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Associazione Italiana per la Ricerca sul Cancro","keywords":"Epigenetics; Exome sequencing; Cancer research; Hematologic malignancy; Bromodomain; Malignancy; Exome; Epigenesis; Biology; Medicine; Gene; Genetics; Mutation; DNA methylation; Internal medicine; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0002305894,0.0003565958,0.0006586801,0.0002321668,0.0003186755,0.00006689164,0.0002578486,0.0002528853,0.00199489],"category_scores_gemma":[0.0002656121,0.0003006143,0.0001562303,0.0003783858,0.0005718574,0.00006459648,0.0001410126,0.0002771189,0.002888955],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002977348,"about_ca_system_score_gemma":0.000553252,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002161399,"about_ca_topic_score_gemma":0.00002426502,"domain_scores_codex":[0.9973254,0.0002070005,0.0004859334,0.0006471204,0.0005824012,0.00075215],"domain_scores_gemma":[0.9982952,0.0003860772,0.0001311408,0.0005734235,0.000332917,0.0002812142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01601165,0.006617144,0.264021,0.004636248,0.001499761,0.0107622,0.008142255,0.0004325547,0.6349474,0.00687348,0.01485331,0.03120301],"study_design_scores_gemma":[0.01995505,0.01718898,0.1759018,0.0007557282,0.001252575,0.07398028,0.002743479,0.05351777,0.5390845,0.05188787,0.05983552,0.003896502],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9594571,0.001436987,0.002315986,0.0007726009,0.0001897939,0.001251619,0.00001182906,0.000180263,0.03438381],"genre_scores_gemma":[0.9906836,0.0001645809,0.00392336,0.001598907,0.0001534522,0.00009901116,0.00007363215,0.00006852556,0.003234927],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09586288,"threshold_uncertainty_score":0.9999446,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01868401955377211,"score_gpt":0.2812417373954823,"score_spread":0.2625577178417102,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}