{"id":"W2899242749","doi":"10.1002/cncr.31779","title":"ABOUND.2L+: A randomized phase 2 study of nanoparticle albumin‐bound paclitaxel with or without CC‐486 as second‐line treatment for advanced nonsquamous non‐small cell lung cancer (NSCLC)","year":2018,"lang":"en","type":"article","venue":"Cancer","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Celgene","keywords":"Medicine; Paclitaxel; Hazard ratio; Clinical endpoint; Internal medicine; Lung cancer; Randomized controlled trial; Oncology; Confidence interval; Progression-free survival; Gastroenterology; Surgery; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001713362,0.002085689,0.00191252,0.0005061793,0.0003519398,0.001223641,0.0008949742,0.002033943,0.006706356],"category_scores_gemma":[0.001031942,0.0009246459,0.001323822,0.0002966639,0.0009985141,0.0009857904,0.0004038211,0.00293492,0.001296092],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008424103,"about_ca_system_score_gemma":0.001198721,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000719593,"about_ca_topic_score_gemma":0.001659808,"domain_scores_codex":[0.9995447,0.0002375726,0.00002045536,0.00008065192,0.00004406764,0.00007249751],"domain_scores_gemma":[0.9995111,0.0001090891,0.0001174301,0.0000360997,0.00003348006,0.0001927711],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.936148,0.02501511,0.000979432,0.0005397883,0.000744151,0.00009471954,0.00006963723,0.0006198672,0.01338884,0.000181789,0.001623232,0.02059548],"study_design_scores_gemma":[0.9155259,0.081389,0.0007454843,0.00001327165,0.0002315828,0.00004682956,0.00001023606,0.000392146,0.0008173009,0.00007833431,0.0007398762,0.00001002832],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875893,0.002212413,0.0007282592,0.0008938655,0.0005031817,0.00462727,0.001099844,0.0001645534,0.002181333],"genre_scores_gemma":[0.9775268,0.002340774,0.002421307,0.001825813,0.0005606965,0.00667745,0.002139537,0.00005645648,0.006451076],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006706356,"threshold_uncertainty_score":0.02243501,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02265636841616333,"score_gpt":0.3902585481138988,"score_spread":0.3676021796977355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}