{"id":"W2899256508","doi":"10.1534/genetics.118.301456","title":"Transgenerational Epigenetic Inheritance Is Negatively Regulated by the HERI-1 Chromodomain Protein","year":2018,"lang":"en","type":"article","venue":"Genetics","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences; National Institutes of Health","keywords":"RNA interference; Biology; Chromodomain; Genetics; Epigenetics; Gene silencing; RNA silencing; Gene; Genetic screen; Cell biology; RNA; Mutant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001410739,0.000226679,0.0001273214,0.00001976914,0.0002023776,0.00004435069,0.0003174992,0.0001598581,0.0001198229],"category_scores_gemma":[0.00002181336,0.0001934231,0.00007692462,0.0001577974,0.0002639072,0.000002421867,0.00006287028,0.00009345885,0.00002995165],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001447955,"about_ca_system_score_gemma":0.00007268429,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000675099,"about_ca_topic_score_gemma":0.00006538013,"domain_scores_codex":[0.9987192,0.0000630124,0.0002563756,0.0004073008,0.0002131588,0.0003409828],"domain_scores_gemma":[0.9992226,0.000006979982,0.00005730419,0.0004860956,0.0001360511,0.00009097104],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002236565,0.0000259625,0.0000931288,0.000008008539,0.00004559743,5.700962e-7,0.0001869631,0.0002376538,0.983318,0.00002661088,0.01295012,0.003085055],"study_design_scores_gemma":[0.0003610025,0.000311613,0.0013064,0.000009787818,0.0000137529,0.00001283755,0.00003503457,0.0009784593,0.8840431,0.0001481689,0.1125374,0.0002424161],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9324141,0.003798148,0.06184912,0.0007855002,0.0001461467,0.0004231347,0.00007086922,0.00002251011,0.0004904768],"genre_scores_gemma":[0.9899489,0.0001436656,0.006400643,0.0005727024,0.0006414345,0.00006372498,0.00007326519,0.00004831537,0.002107327],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09958732,"threshold_uncertainty_score":0.7887564,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009120461304376815,"score_gpt":0.2721878289833146,"score_spread":0.2630673676789378,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}