{"id":"W2899277949","doi":"10.3390/cells7110188","title":"Neuronal Ceroid Lipofuscinoses: Connecting Calcium Signalling through Calmodulin","year":2018,"lang":"en","type":"article","venue":"Cells","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trent University; University of Toronto; Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada; Killam Trusts; Nova Scotia Health Research Foundation; Banting Research Foundation","keywords":"Batten disease; Calmodulin; Calcium signaling; Calcium-binding protein; Calcium; Biology; Cell biology; Signalling; Cathepsin D; Neuroscience; Biochemistry; Chemistry; Signal transduction; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.000211531,0.0001831972,0.0002827245,0.00007056357,0.0002023115,0.00004645226,0.0001918247,0.0001192422,0.002055306],"category_scores_gemma":[0.0002228602,0.0001650472,0.0001138399,0.0003095161,0.0002044253,0.0001187513,0.000124095,0.0003733134,0.001443888],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009256502,"about_ca_system_score_gemma":0.0001323393,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000277888,"about_ca_topic_score_gemma":0.00002085015,"domain_scores_codex":[0.9981705,0.000068742,0.0002664894,0.0004467542,0.0004873509,0.0005601586],"domain_scores_gemma":[0.9989966,0.0001677824,0.00006309247,0.0003163603,0.0002527752,0.0002034198],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002763728,0.0002778977,0.001788572,0.0001609795,0.00007016623,0.0002068129,0.001931559,0.00003298515,0.9820011,0.0001251909,0.006615938,0.006512416],"study_design_scores_gemma":[0.001772458,0.0009522929,0.00116437,0.000111252,0.00005274998,0.0000671085,0.0006555083,0.002530068,0.9327062,0.0002230317,0.0594723,0.0002926287],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9680201,0.0003409379,0.004521348,0.0006923348,0.0004874072,0.0003968495,0.000006718208,0.0001287748,0.02540546],"genre_scores_gemma":[0.9940546,0.00002642345,0.001916125,0.001027441,0.001186754,0.0000083048,0.00001276782,0.00005437347,0.001713243],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05285637,"threshold_uncertainty_score":0.9993336,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05816445441093021,"score_gpt":0.33462601529587,"score_spread":0.2764615608849398,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}