{"id":"W2899287906","doi":"10.1136/lupus-2018-lsm.9","title":"AI-09 T follicular helper (Tfh) cells are increased in asymptomatic anti-nuclear antibody (ANA)<sup>+</sup> individuals and appear to play a role in epitope spreading","year":2018,"lang":"en","type":"article","venue":"","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Lakeridge Health; Mount Sinai Hospital; University of Toronto; University Health Network","funders":"Lupus Research Alliance; National Center for Advancing Translational Sciences; University of Florida; Lupus Research Institute; National Institutes of Health; National Institute of Allergy and Infectious Diseases; National Psoriasis Foundation","keywords":"Medicine; Asymptomatic; Antibody; Immunology; Flow cytometry; Memory B cell; Immune system; FOXP3; B cell; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001342494,0.0002577379,0.0001547044,0.0006204634,0.0002142547,0.0003739587,0.0001600669,0.0004006292,0.004677545],"category_scores_gemma":[0.0004484977,0.0001485634,0.0001266241,0.0002595539,0.0001769795,0.0001885142,0.000124648,0.0002692234,0.0006063022],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009824376,"about_ca_system_score_gemma":0.00005831895,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005622925,"about_ca_topic_score_gemma":0.0005380297,"domain_scores_codex":[0.9998919,0.00001745616,0.00001616326,0.00003251261,0.00002166645,0.00002024588],"domain_scores_gemma":[0.9996137,0.00005343997,0.0001755956,0.0000266253,0.00004349332,0.00008710207],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003252375,0.0002993487,0.7517363,0.0001707295,0.00007288355,0.002231042,0.0003789804,0.00006753213,0.2263439,0.00009457757,0.001022508,0.01432985],"study_design_scores_gemma":[0.00003015471,0.0005326137,0.9897463,0.00001033974,0.00003382092,0.004168563,0.0002180248,0.000124213,0.004487386,0.00006718502,0.0005764806,0.000004855814],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988224,0.0002152093,0.0001008891,0.00002085829,0.000006659249,0.000009091462,0.0002443266,0.00001594612,0.0005645819],"genre_scores_gemma":[0.9989219,0.00008224157,0.0001722828,0.00004133544,0.0000182516,0.00001179736,0.0002314642,0.000003828487,0.0005169444],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004677545,"threshold_uncertainty_score":0.01564789,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004413475223595359,"score_gpt":0.2255404509617605,"score_spread":0.2211269757381651,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}