{"id":"W2899304056","doi":"10.1159/000491705","title":"Octadecyloxyethyl Adefovir Exhibits Potent in vitro and in vivo Cytotoxic Activity and Has Synergistic Effects with Ara-C in Acute Myeloid Leukemia","year":2018,"lang":"en","type":"article","venue":"Chemotherapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Ontario Institute for Cancer Research","funders":"","keywords":"Myeloid leukemia; In vivo; Cytotoxic T cell; In vitro; Pharmacology; Leukemia; Adefovir; Cytotoxicity; Chemistry; Medicine; Cancer research; Biology; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001745534,0.0003034936,0.0005264043,0.0003105724,0.0000492381,0.00003018262,0.00005427993,0.0001396932,0.00001886197],"category_scores_gemma":[0.00002162574,0.0002320162,0.00002617063,0.0003718039,0.000233407,0.0001058957,0.00002651806,0.0002311756,0.000007308221],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004537272,"about_ca_system_score_gemma":0.0001884579,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001304865,"about_ca_topic_score_gemma":0.0004613407,"domain_scores_codex":[0.998671,0.0000528968,0.0002107991,0.0004830593,0.0001969533,0.000385292],"domain_scores_gemma":[0.9994553,0.0001071464,0.00006237831,0.0002133253,0.00002163768,0.0001402461],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004499412,0.0004139569,0.06432424,0.0001632628,0.0001449199,0.0007296933,0.003241223,0.000001172906,0.901162,0.000005639762,0.0001538692,0.02516061],"study_design_scores_gemma":[0.01198754,0.0003442108,0.2381758,0.0004104628,0.00003150413,0.00005522499,0.00004873153,0.0003460527,0.7479646,0.00004813206,0.0003411782,0.0002465315],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968188,0.0003160967,0.00005170661,0.001530737,0.00003308339,0.0008159145,0.000003224369,0.00003268002,0.0003978054],"genre_scores_gemma":[0.9968076,0.0004106588,0.0009303404,0.0003945568,0.00005172544,0.00008990064,0.000005836162,0.00003924999,0.001270136],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1738516,"threshold_uncertainty_score":0.9461344,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008264345592563787,"score_gpt":0.2367896343255318,"score_spread":0.228525288732968,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}