{"id":"W2899304056","doi":"10.1159/000491705","title":"Octadecyloxyethyl Adefovir Exhibits Potent in vitro and in vivo Cytotoxic Activity and Has Synergistic Effects with Ara-C in Acute Myeloid Leukemia","year":2018,"lang":"en","type":"article","venue":"Chemotherapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Ontario Institute for Cancer Research","funders":"","keywords":"Myeloid leukemia; In vivo; Cytotoxic T cell; In vitro; Pharmacology; Leukemia; Adefovir; Cytotoxicity; Chemistry; Medicine; Cancer research; Biology; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001770719,0.0003466807,0.0003738404,0.0003460216,0.00009915055,0.0002635221,0.000151045,0.0001376553,0.0007447138],"category_scores_gemma":[0.0001342711,0.0001486761,0.000218524,0.0002848445,0.0001135956,0.0001185775,0.0001541251,0.0003845455,0.0001761615],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001774021,"about_ca_system_score_gemma":0.0001957525,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009585817,"about_ca_topic_score_gemma":0.001612955,"domain_scores_codex":[0.9998733,0.00003073944,0.00001335848,0.00001876303,0.00004090249,0.00002292571],"domain_scores_gemma":[0.9999403,0.00002044668,0.000008888101,0.000009561949,0.000007813827,0.00001296256],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004743415,0.0001925083,0.000397818,0.00006656678,0.00001545269,0.00006432306,0.00001487842,0.0006957785,0.9852403,0.00006115629,0.00009922669,0.01267746],"study_design_scores_gemma":[0.00005339757,0.001572083,0.002870491,0.000006182013,0.00003174388,0.0002912528,0.000008948086,0.0007781795,0.9911525,0.00002451702,0.003205237,0.000005445346],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898115,0.004730532,0.001884878,0.00006034943,0.00002059471,0.00006984937,0.0005593696,0.00006392708,0.002798957],"genre_scores_gemma":[0.9911205,0.003528761,0.002299282,0.00002932133,0.000008444374,0.00002559023,0.0008573911,0.00001578024,0.00211505],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009585817,"threshold_uncertainty_score":0.002491295,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008264345592563787,"score_gpt":0.2367896343255318,"score_spread":0.228525288732968,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}