{"id":"W2899326228","doi":"10.1038/s41467-018-07127-8","title":"TAp73-induced phosphofructokinase-1 transcription promotes the Warburg effect and enhances cell proliferation","year":2018,"lang":"en","type":"article","venue":"Nature Communications","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Cancer Institute; National Institutes of Health; Tsinghua University; National Natural Science Foundation of China; U.S. Department of Defense","keywords":"Warburg effect; Glycolysis; Phosphofructokinase; Cell biology; Cancer research; Regulator; Cell growth; Transcription factor; Suppressor; Biology; Anaerobic glycolysis; Chemistry; Biochemistry; Metabolism; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002783962,0.0001271686,0.0001037905,0.00002686787,0.0004257435,0.00004876331,0.0004237645,0.0002470549,0.000007014557],"category_scores_gemma":[0.00007756628,0.00009166411,0.0000546715,0.0001232235,0.0001959269,0.00001000347,0.00009915935,0.0003169327,0.000004715906],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008049832,"about_ca_system_score_gemma":0.00005279276,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002227231,"about_ca_topic_score_gemma":0.0004966655,"domain_scores_codex":[0.9992476,0.0001722371,0.0001323345,0.0002108343,0.00009823759,0.0001387984],"domain_scores_gemma":[0.9987474,0.00003520145,0.00007091925,0.0009588191,0.0001457647,0.0000418892],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003945925,0.00004049711,0.0002241545,0.00001010883,0.00001894546,2.11873e-8,0.0003149681,1.375597e-7,0.9872962,0.0002264028,0.002369014,0.00946005],"study_design_scores_gemma":[0.0002988213,0.0002011278,0.001720669,0.000008395974,0.00004142052,0.000005536127,0.00003894199,0.00005609888,0.743321,0.00005196892,0.2541549,0.0001011294],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9667628,0.02861325,0.0001416492,0.001445456,0.0006652097,0.0005952124,0.00001580773,0.00002500228,0.001735645],"genre_scores_gemma":[0.9946395,0.002987782,0.0005675303,0.000397539,0.0008183173,0.0001266386,0.0001239554,0.00001495035,0.0003238319],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2517859,"threshold_uncertainty_score":0.3737954,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009271921276831036,"score_gpt":0.2712526419101443,"score_spread":0.2619807206333132,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}