{"id":"W2899337283","doi":"10.1210/en.2018-00649","title":"Immune Response to Extracellular Vesicles From Human Islets of Langerhans in Patients With Type 1 Diabetes","year":2018,"lang":"en","type":"article","venue":"Endocrinology","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Canadian Natural Resources","funders":"McGill University Health Centre; Canadian Donation and Transplantation Research Program","keywords":"Immune system; Islet; Peripheral blood mononuclear cell; Proinflammatory cytokine; T cell; Immunology; Biology; Autoantibody; Cytokine; Endocrinology; Antibody; Internal medicine; Inflammation; Medicine; Diabetes mellitus; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009565,0.000148739,0.0001948334,0.00009606215,0.00003866915,0.000005853366,0.0002749241,0.00008853867,0.0001003625],"category_scores_gemma":[0.0001428454,0.000142275,0.00003667603,0.0001272971,0.000214639,0.000004094715,0.0001609171,0.00007835147,0.00004806585],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001549691,"about_ca_system_score_gemma":0.00003576838,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004161293,"about_ca_topic_score_gemma":0.00003643448,"domain_scores_codex":[0.9987741,0.0001689537,0.0002520267,0.0003518577,0.0001045389,0.0003485336],"domain_scores_gemma":[0.999153,0.00002922472,0.00008514507,0.0005516495,0.0001093821,0.0000715631],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001162517,0.0001786818,0.1332864,0.000004671286,0.00004011795,0.0000112683,0.00009415709,0.000003743134,0.8643649,0.00003754309,0.0001935655,0.00062244],"study_design_scores_gemma":[0.0008992976,0.00120946,0.3554856,0.00001469378,0.00001168939,3.750829e-7,0.00002527216,0.000001278945,0.6387272,0.00006849755,0.003426934,0.0001296124],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983269,0.00105221,0.00004297879,0.00007526562,0.0001074965,0.0002003561,0.00003877666,0.00001320145,0.0001427985],"genre_scores_gemma":[0.9988169,0.000005811713,0.0006207289,0.00009182301,0.00009425723,0.00001380276,0.0001376142,0.00002972932,0.0001893171],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2256376,"threshold_uncertainty_score":0.5801806,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00686835165063165,"score_gpt":0.236852431322836,"score_spread":0.2299840796722043,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}