{"id":"W2899337283","doi":"10.1210/en.2018-00649","title":"Immune Response to Extracellular Vesicles From Human Islets of Langerhans in Patients With Type 1 Diabetes","year":2018,"lang":"en","type":"article","venue":"Endocrinology","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Canadian Natural Resources","funders":"McGill University Health Centre; Canadian Donation and Transplantation Research Program","keywords":"Immune system; Islet; Peripheral blood mononuclear cell; Proinflammatory cytokine; T cell; Immunology; Biology; Autoantibody; Cytokine; Endocrinology; Antibody; Internal medicine; Inflammation; Medicine; Diabetes mellitus; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002097612,0.0002778367,0.0003262167,0.0004952966,0.000358824,0.0004501952,0.0001190564,0.000460142,0.001536533],"category_scores_gemma":[0.0007689785,0.0001397365,0.0001915339,0.0003490687,0.0001752055,0.000316256,0.0002581676,0.0004186115,0.0001698917],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001579782,"about_ca_system_score_gemma":0.00006609411,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002997086,"about_ca_topic_score_gemma":0.0001881717,"domain_scores_codex":[0.9998482,0.00003831247,0.00002010078,0.00004976756,0.00002157108,0.00002197179],"domain_scores_gemma":[0.9997678,0.00006629168,0.00008942479,0.00001660537,0.00002026482,0.00003965833],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003175425,0.0002093222,0.9280506,0.0001567218,0.0001216,0.00791306,0.0005523061,0.0001431199,0.02843663,0.0001281493,0.0008927583,0.03022028],"study_design_scores_gemma":[0.00005567828,0.0008460571,0.9655659,0.0000537612,0.0001612708,0.02614788,0.000624408,0.0003609603,0.00394488,0.0001757146,0.002048395,0.00001504325],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975083,0.001481137,0.0001095441,0.00008244198,0.00002040567,0.000006415401,0.00007280435,0.000009832759,0.000709053],"genre_scores_gemma":[0.9992983,0.0002919515,0.00007568679,0.0000630565,0.00002023764,0.000002739405,0.00007319741,0.000002173205,0.000172643],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001536533,"threshold_uncertainty_score":0.005140185,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00686835165063165,"score_gpt":0.236852431322836,"score_spread":0.2299840796722043,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}