{"id":"W2899339394","doi":"10.1016/j.celrep.2018.10.018","title":"Insulin Secretion Depends on Intra-islet Glucagon Signaling","year":2018,"lang":"en","type":"article","venue":"Cell Reports","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":352,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"Banting and Best Diabetes Centre, University of Toronto; Canadian Institutes of Health Research; Novo Nordisk Fonden; Novo Nordisk; Danmarks Frie Forskningsfond; Carlsbergfondet; H. Lundbeck A/S; Lundbeckfonden; Canada Research Chairs","keywords":"Glucagon receptor; Glucagon; Islet; Internal medicine; Endocrinology; Insulin; Proglucagon; Biology; Paracrine signalling; Receptor; Glucagon-like peptide 1 receptor; Glucose homeostasis; Secretion; Glucagon-like peptide-1; Type 2 diabetes; Diabetes mellitus; Agonist; Insulin resistance; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002775518,0.000119389,0.0001969715,0.0000957295,0.00007264816,0.000016515,0.00002196984,0.0001000906,0.001455243],"category_scores_gemma":[0.0002859822,0.0001004169,0.00006502763,0.000142953,0.00005400033,0.00003893421,0.00001339616,0.0001271166,0.0002879859],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005552268,"about_ca_system_score_gemma":0.00007971629,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001837241,"about_ca_topic_score_gemma":6.709944e-7,"domain_scores_codex":[0.9989538,0.00002320986,0.0003048349,0.0002776152,0.000247873,0.0001926399],"domain_scores_gemma":[0.9992043,0.00005003592,0.0001439005,0.0003348031,0.0001149275,0.0001520397],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002626989,0.0002805452,0.01325438,0.00009569764,0.00003938262,0.0007831273,0.0003223607,0.000007627141,0.9635149,0.00006649495,0.009383541,0.0119893],"study_design_scores_gemma":[0.000585522,0.0006713863,0.003408026,0.0001146557,0.00007079843,0.0001834675,0.0000692653,0.0002256385,0.9506015,0.0002711734,0.04366978,0.0001288324],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8618037,0.0001098174,0.0003570344,0.0001296349,0.0006809005,0.0001392115,6.081556e-7,0.0001004062,0.1366787],"genre_scores_gemma":[0.9935349,0.00001436236,0.0004351585,0.001151648,0.0007786331,0.000009625937,0.00005112935,0.00001931488,0.004005175],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1326735,"threshold_uncertainty_score":0.9994575,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0146446046181923,"score_gpt":0.2471373946297239,"score_spread":0.2324927900115316,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}