{"id":"W2899339394","doi":"10.1016/j.celrep.2018.10.018","title":"Insulin Secretion Depends on Intra-islet Glucagon Signaling","year":2018,"lang":"en","type":"article","venue":"Cell Reports","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":352,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"Banting and Best Diabetes Centre, University of Toronto; Canadian Institutes of Health Research; Novo Nordisk Fonden; Novo Nordisk; Danmarks Frie Forskningsfond; Carlsbergfondet; H. Lundbeck A/S; Lundbeckfonden; Canada Research Chairs","keywords":"Glucagon receptor; Glucagon; Islet; Internal medicine; Endocrinology; Insulin; Proglucagon; Biology; Paracrine signalling; Receptor; Glucagon-like peptide 1 receptor; Glucose homeostasis; Secretion; Glucagon-like peptide-1; Type 2 diabetes; Diabetes mellitus; Agonist; Insulin resistance; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003860327,0.0009066776,0.0005308611,0.0009317185,0.000215285,0.0009092292,0.0006300332,0.0004834466,0.007906214],"category_scores_gemma":[0.0002946375,0.0004012518,0.0005500375,0.0003872257,0.0006352476,0.0007461882,0.0003757252,0.002152601,0.001923398],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00028093,"about_ca_system_score_gemma":0.0002501684,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001581606,"about_ca_topic_score_gemma":0.0003237379,"domain_scores_codex":[0.9995151,0.00004984749,0.00005394334,0.0001546254,0.0001384763,0.0000880309],"domain_scores_gemma":[0.9993829,0.00007087137,0.0001639406,0.0000984848,0.00003239178,0.0002514842],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008201255,0.00008285506,0.0004580893,0.0000383862,0.00001402232,0.0001549209,0.00001542427,0.00002663716,0.9963748,0.0002905857,0.0001188169,0.001605242],"study_design_scores_gemma":[0.000194743,0.0006420384,0.01323448,0.00002748007,0.00007382909,0.001826102,0.00009389543,0.0007078848,0.9777167,0.0004364172,0.005024478,0.00002192472],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9761213,0.002133288,0.009848367,0.0004298121,0.0004341687,0.0000464862,0.002136146,0.000866071,0.007984344],"genre_scores_gemma":[0.9758825,0.00150407,0.006356807,0.0002853087,0.000076431,0.0001111243,0.002559555,0.0005503205,0.01267393],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007906214,"threshold_uncertainty_score":0.02644897,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0146446046181923,"score_gpt":0.2471373946297239,"score_spread":0.2324927900115316,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}