{"id":"W2899340054","doi":"10.1210/jc.2018-01504","title":"Hypermethylator Phenotype and Ectopic GIP Receptor in GNAS Mutation-Negative Somatotropinomas","year":2018,"lang":"en","type":"article","venue":"The Journal of Clinical Endocrinology & Metabolism","topic":"Genetic Syndromes and Imprinting","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Fondation pour la Recherche Médicale","keywords":"Acromegaly; GNAS complex locus; Gigantism; Biology; Endocrinology; Internal medicine; Ectopic expression; Phenotype; Allele; Somatotropic cell; DNA methylation; Gene expression; Genetics; Gene; Pituitary gland; Hormone; Medicine; Growth hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007622779,0.0001370428,0.0004313624,0.00006669599,0.00007219888,0.00001152557,0.0002836914,0.0001329389,0.00005889537],"category_scores_gemma":[0.001402054,0.00009159991,0.0001208757,0.00009069938,0.0004934,0.000007555668,0.0001451839,0.0003230649,0.00001748263],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004126856,"about_ca_system_score_gemma":0.0001110026,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002856636,"about_ca_topic_score_gemma":0.0000231236,"domain_scores_codex":[0.998044,0.0005099804,0.0008622762,0.0001844375,0.0001186734,0.0002806078],"domain_scores_gemma":[0.9987525,0.0002478189,0.0004624008,0.0002390748,0.0002064885,0.00009170274],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.00138814,0.0007223432,0.2232598,0.00005762394,0.001543669,0.00006365529,0.002616104,0.00009039196,0.339152,0.004074818,0.002050736,0.4249807],"study_design_scores_gemma":[0.002922009,0.0009615243,0.9291075,0.00002153554,0.000106577,0.0005239142,0.0002856193,0.00004836026,0.028371,0.002181802,0.03529981,0.0001703087],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942946,0.003025669,0.0002710884,0.001130355,0.0009085356,0.00009972361,0.000001610182,0.0000031011,0.000265247],"genre_scores_gemma":[0.9930361,0.001959668,0.002889638,0.0005825341,0.001386794,0.000001977749,0.000001008607,0.00001422729,0.0001280844],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7058477,"threshold_uncertainty_score":0.3735336,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02707681802728478,"score_gpt":0.335985879236039,"score_spread":0.3089090612087542,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}