{"id":"W2899340054","doi":"10.1210/jc.2018-01504","title":"Hypermethylator Phenotype and Ectopic GIP Receptor in GNAS Mutation-Negative Somatotropinomas","year":2018,"lang":"en","type":"article","venue":"The Journal of Clinical Endocrinology & Metabolism","topic":"Genetic Syndromes and Imprinting","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Fondation pour la Recherche Médicale","keywords":"Acromegaly; GNAS complex locus; Gigantism; Biology; Endocrinology; Internal medicine; Ectopic expression; Phenotype; Allele; Somatotropic cell; DNA methylation; Gene expression; Genetics; Gene; Pituitary gland; Hormone; Medicine; Growth hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001440307,0.0002986014,0.0001678937,0.0004831073,0.0001785944,0.0001850979,0.0001348457,0.0002592124,0.001160085],"category_scores_gemma":[0.0004844746,0.0001234911,0.0001093829,0.0002316339,0.0004060552,0.0001063902,0.0002290881,0.0001697735,0.0001520613],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001615883,"about_ca_system_score_gemma":0.0001194848,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004144381,"about_ca_topic_score_gemma":0.0005523228,"domain_scores_codex":[0.999896,0.00001480119,0.00001094605,0.00003424558,0.00002704216,0.00001681609],"domain_scores_gemma":[0.9998252,0.00005593191,0.0000606819,0.00001492063,0.00001358955,0.00002969875],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000752814,0.00002632342,0.3351296,0.00009128777,0.00004172581,0.01680915,0.0003880896,0.0002544196,0.640483,0.00009725534,0.00008057916,0.005845923],"study_design_scores_gemma":[0.00004361815,0.0005025422,0.814921,0.000008799106,0.00007452333,0.1088257,0.0003770449,0.001252937,0.07316633,0.0001896498,0.0006236416,0.00001418818],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994718,0.000074976,0.0002762671,0.00001043703,9.176102e-7,0.000003447524,0.00002363066,0.000009665059,0.0001288182],"genre_scores_gemma":[0.9995847,0.0000316251,0.0002897899,0.000007253711,0.000002607444,0.000003565527,0.00003433622,0.000002760892,0.00004335462],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001160085,"threshold_uncertainty_score":0.003880858,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02707681802728478,"score_gpt":0.335985879236039,"score_spread":0.3089090612087542,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}