{"id":"W2899367089","doi":"10.1007/s13318-018-0525-3","title":"Population Pharmacokinetic Analysis of Immediate-Release Oral Tacrolimus Co-administered with Mycophenolate Mofetil in Corticosteroid-Free Adult Kidney Transplant Recipients","year":2018,"lang":"en","type":"article","venue":"European Journal of Drug Metabolism and Pharmacokinetics","topic":"Renal Transplantation Outcomes and Treatments","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Sciences Centre; University of British Columbia; University of Alberta","funders":"Vancouver Coastal Health Research Institute; F. Hoffmann-La Roche","keywords":"Tacrolimus; Mycophenolic acid; Pharmacokinetics; Population; Medicine; Calcineurin; Pharmacology; Mycophenolate; Renal function; Corticosteroid; Therapeutic drug monitoring; Kidney transplantation; Transplantation; Urology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008060041,0.0003601786,0.0007033974,0.0002816855,0.0002037574,0.0007191559,0.0002935228,0.0004563672,0.000897843],"category_scores_gemma":[0.002120386,0.0002281551,0.000926339,0.0003412355,0.0002750753,0.0005525353,0.0002810948,0.0007732132,0.0001604219],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004312293,"about_ca_system_score_gemma":0.0003793871,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001012977,"about_ca_topic_score_gemma":0.0007288925,"domain_scores_codex":[0.9994367,0.0001877899,0.00004008773,0.0001435593,0.0001024567,0.00008948721],"domain_scores_gemma":[0.9989834,0.0003908817,0.000298264,0.0001278143,0.00006813403,0.0001314093],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.05207816,0.002022595,0.883945,0.0001087652,0.002923764,0.001401191,0.000433961,0.004428876,0.01892316,0.0003087923,0.0006688826,0.03275681],"study_design_scores_gemma":[0.0004562488,0.009911325,0.9739833,0.000008297138,0.00111199,0.0015299,0.0002505867,0.009996842,0.001950704,0.0002183087,0.0005323057,0.00005001467],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996256,0.00007169574,0.0001464236,0.00001042293,0.000002283093,0.000004858522,0.00004149487,0.000006650788,0.00009053724],"genre_scores_gemma":[0.9996898,0.00002858706,0.00007647888,0.00001639905,0.000005961281,0.00000449713,0.0001045754,0.000003344039,0.0000704717],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001012977,"threshold_uncertainty_score":0.004262626,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01677122219796305,"score_gpt":0.2937207457109209,"score_spread":0.2769495235129579,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}