{"id":"W2899396140","doi":"10.1016/j.brainres.2018.10.032","title":"MiR-105 and miR-9 regulate the mRNA stability of neuronal intermediate filaments. Implications for the pathogenesis of amyotrophic lateral sclerosis (ALS)","year":2018,"lang":"en","type":"article","venue":"Brain Research","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"E-Rare","keywords":"Amyotrophic lateral sclerosis; Intermediate filament; Pathogenesis; Biology; Messenger RNA; microRNA; Motor neuron; Protein filament; Cell biology; Gene expression; Neuroscience; Spinal cord; Gene; Cell; Disease; Genetics; Medicine; Cytoskeleton; Immunology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.003678554,0.0001837732,0.0003902322,0.0001856623,0.0004858962,0.00005352786,0.0006630509,0.0001242408,0.0002989648],"category_scores_gemma":[0.001741164,0.0001022257,0.0001747382,0.0007075542,0.003175919,0.00009534449,0.0005989841,0.0004336346,0.00001063343],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009251087,"about_ca_system_score_gemma":0.0002527274,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000383221,"about_ca_topic_score_gemma":0.0000889233,"domain_scores_codex":[0.9965443,0.0006819363,0.000602154,0.0005084061,0.0009384897,0.0007247409],"domain_scores_gemma":[0.9944679,0.002742569,0.000147334,0.00117494,0.001254293,0.0002130039],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001081607,0.0002176352,0.03346643,0.0002274779,0.0001418165,7.62018e-7,0.000745705,0.000001200857,0.945419,0.0005134699,0.004250647,0.01393424],"study_design_scores_gemma":[0.001133299,0.001023817,0.9773996,0.0001219228,0.0000355829,0.000006103838,0.0001018369,0.0007298518,0.01711688,0.0009466775,0.00129845,0.00008598245],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9594176,0.0002909116,0.00005742912,0.03777095,0.00005753357,0.002042555,0.0002474472,0.00001709539,0.00009840473],"genre_scores_gemma":[0.9980814,0.0003322546,0.0002431146,0.0002712586,0.0002175225,0.0003735593,0.00002231147,0.0000407599,0.0004177644],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9439332,"threshold_uncertainty_score":0.9995369,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1613875514347143,"score_gpt":0.3925956989293682,"score_spread":0.2312081474946539,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}