{"id":"W2899436946","doi":"10.1016/j.lungcan.2018.10.028","title":"Impact of afatinib dose modification on safety and effectiveness in patients with EGFR mutation-positive advanced NSCLC: Results from a global real-world study (RealGiDo)","year":2018,"lang":"en","type":"article","venue":"Lung Cancer","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"Boehringer Ingelheim","keywords":"Medicine; Afatinib; Tolerability; Adverse effect; Internal medicine; Incidence (geometry); Medical record; Observational study; Oncology; Surgery; Epidermal growth factor receptor; Cancer; Gefitinib","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004564045,0.0004176276,0.0006569915,0.0001870306,0.0001503447,0.0009089945,0.000348468,0.0005173847,0.001027724],"category_scores_gemma":[0.003918046,0.0001723427,0.001490431,0.0004513343,0.0005258006,0.0006072642,0.0004317442,0.0008591887,0.0001841501],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008182747,"about_ca_system_score_gemma":0.0005798393,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001006354,"about_ca_topic_score_gemma":0.001541743,"domain_scores_codex":[0.9974664,0.001690509,0.0001869647,0.0003157546,0.000212379,0.0001279656],"domain_scores_gemma":[0.9963202,0.0009757087,0.001810804,0.0003951691,0.0001817937,0.0003162861],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.3328979,0.008360688,0.5299218,0.001203001,0.01004294,0.0002497585,0.0004904493,0.004191438,0.005632099,0.0002181938,0.002842434,0.1039493],"study_design_scores_gemma":[0.07937917,0.1282811,0.7812322,0.00008438662,0.003290741,0.0005263587,0.000227323,0.002114425,0.001462703,0.0001878733,0.003132223,0.00008139006],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978453,0.00106397,0.0001482793,0.0001055802,0.00001110169,0.00005510382,0.0003862765,0.00001176986,0.0003727165],"genre_scores_gemma":[0.9987195,0.0002689174,0.0001726139,0.0001441378,0.00002038896,0.00004011631,0.000560865,0.000004418713,0.00006917609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004564045,"threshold_uncertainty_score":0.02413726,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008844275390835923,"score_gpt":0.3752341129827568,"score_spread":0.3663898375919209,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}