{"id":"W2899438746","doi":"10.3389/fimmu.2018.02407","title":"GDF15 Regulates Malat-1 Circular RNA and Inactivates NFκB Signaling Leading to Immune Tolerogenic DCs for Preventing Alloimmune Rejection in Heart Transplantation","year":2018,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"GDF15 and Related Biomarkers","field":"Medicine","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; London Health Sciences Centre; Western University","funders":"Canadian Institutes of Health Research","keywords":"Immune system; Cell biology; Immune tolerance; Transplantation; Transforming growth factor; Signal transduction; Immunology; Cancer research; Biology; Conditional gene knockout; Receptor; Medicine; Phenotype; Gene; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001589824,0.000244649,0.0002373595,0.0001908863,0.0001156449,0.0002422663,0.0001529237,0.0002176135,0.0008208985],"category_scores_gemma":[0.00007987179,0.0001254372,0.0003476252,0.00009837106,0.0002198146,0.0001411009,0.0001735364,0.0005371356,0.0002252958],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002886318,"about_ca_system_score_gemma":0.0002395372,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003985473,"about_ca_topic_score_gemma":0.0007760744,"domain_scores_codex":[0.9998534,0.00002145613,0.0000156677,0.0000339662,0.00003369663,0.00004183755],"domain_scores_gemma":[0.9999427,0.000005238664,0.00001930875,0.000005241087,0.000006987527,0.00002053512],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001221068,0.0000279812,0.0002427705,0.00005080618,0.000004153533,0.00002579205,0.000009833854,0.00005628764,0.9981828,0.00006872301,0.00004035854,0.0011685],"study_design_scores_gemma":[0.00003915514,0.0002770473,0.003214343,0.000009485345,0.00002291159,0.0001361032,0.0000252594,0.0007564656,0.9926334,0.00004046495,0.002841688,0.000003604398],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913262,0.003390871,0.003477649,0.0001587686,0.00007874844,0.00006290827,0.0003430562,0.00008558773,0.00107622],"genre_scores_gemma":[0.9937577,0.001272939,0.002715747,0.0001052949,0.00001283924,0.00005493622,0.0004194488,0.00001646658,0.001644621],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008208985,"threshold_uncertainty_score":0.002746224,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008784955824701934,"score_gpt":0.2462941921962455,"score_spread":0.2375092363715435,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}