{"id":"W2899451374","doi":"10.1016/j.celrep.2018.10.021","title":"Integrated Stress Response Activity Marks Stem Cells in Normal Hematopoiesis and Leukemia","year":2018,"lang":"en","type":"article","venue":"Cell Reports","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":135,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"Canadian Institutes of Health Research; EMBO; Canadian Cancer Society Research Institute; Terry Fox Foundation; Ontario Genomics; Canada Research Chairs; European Commission; Ontario Ministry of Health and Long-Term Care; Ontario Genomics Institute; Princess Margaret Hospital Foundation; Leukemia and Lymphoma Society; Genome Canada; Hospital for Sick Children; Human Frontier Science Program; Ontario Institute for Cancer Research; European Molecular Biology Organization","keywords":"Haematopoiesis; Stem cell; Leukemia; Cell biology; Biology; Fight-or-flight response; Cancer research; Immunology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002459639,0.0001655771,0.0001610928,0.00005041114,0.00005793087,0.00003347685,0.00006789696,0.0001513497,0.00003755953],"category_scores_gemma":[0.00004513613,0.0001503667,0.00005182764,0.00008036976,0.000146755,0.000006630307,0.0001215129,0.00009130339,0.00000379978],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003423499,"about_ca_system_score_gemma":0.0001880202,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000110828,"about_ca_topic_score_gemma":0.00009148881,"domain_scores_codex":[0.9988705,0.0001078704,0.0002345694,0.0004297959,0.000111019,0.0002462404],"domain_scores_gemma":[0.9992183,0.00002404287,0.0001310568,0.0004134851,0.0000658944,0.0001471626],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009906141,0.00009213536,0.02665645,0.00005931095,0.00001313075,0.0006131569,0.00007756177,0.00001846295,0.9685541,0.000001521757,0.001700765,0.001222742],"study_design_scores_gemma":[0.0003288959,0.0001384419,0.01318517,0.00003277099,0.00001228848,0.00007776362,0.000144846,0.0001002933,0.9814641,0.000008278505,0.004321382,0.0001857314],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964664,0.000238341,0.00008171106,0.00001703157,0.0001649428,0.0001427088,0.00002096755,0.00001184848,0.002856062],"genre_scores_gemma":[0.9979171,0.00006051648,0.00009277691,0.00004436693,0.00006274444,0.00001575104,0.00001948895,0.00001760849,0.001769706],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01347127,"threshold_uncertainty_score":0.6131778,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005359715588239757,"score_gpt":0.2171699309844817,"score_spread":0.211810215396242,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}