{"id":"W2899462292","doi":"10.1038/s41416-018-0230-7","title":"Tumour budding is associated with the mesenchymal colon cancer subtype and RAS/RAF mutations: a study of 1320 colorectal cancers with Consensus Molecular Subgroup (CMS) data","year":2018,"lang":"en","type":"article","venue":"British Journal of Cancer","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Innovatiefonds Zorgverzekeraars; KWF Kankerbestrijding; ZonMw; Mach-Gaensslen Foundation of Canada; New York Stem Cell Foundation","keywords":"KRAS; Colorectal cancer; Tumor budding; Budding; Pathology; Cancer research; Biology; Epithelial–mesenchymal transition; Phenotype; Oncology; Tissue microarray; Immunohistochemistry; Medicine; Cancer; Internal medicine; Gene; Metastasis; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003135691,0.0001971637,0.0006185072,0.00007751481,0.0002666742,0.00005677687,0.0001754868,0.0000502485,0.00009857526],"category_scores_gemma":[0.0001268786,0.0001340921,0.00004549421,0.0004283976,0.0005116698,0.0001094211,0.00007561698,0.0002672033,1.928977e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003980225,"about_ca_system_score_gemma":0.001006283,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.01657717,"about_ca_topic_score_gemma":0.1454957,"domain_scores_codex":[0.998322,0.0001023382,0.000386966,0.0002925285,0.0006234103,0.000272782],"domain_scores_gemma":[0.9978648,0.0001413134,0.0006125776,0.0001666685,0.001096058,0.0001185205],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02327956,0.001718251,0.8649809,0.0001874942,0.01846664,0.007454465,0.01972723,0.0003649213,0.01040161,0.00001560113,0.01667449,0.03672887],"study_design_scores_gemma":[0.02031321,0.01508022,0.9335356,0.002650865,0.004926379,0.002696099,0.01433597,0.00043514,0.004334854,0.00001446146,0.001232184,0.0004450109],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9816656,0.01607593,0.000006471153,0.001007465,0.0001436764,0.0006253091,0.0002434335,0.00001005413,0.0002220971],"genre_scores_gemma":[0.9980177,0.00129927,0.00006684021,0.0002553602,0.0001721725,0.0000600787,0.000007302943,0.00003121126,0.00009010849],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1289185,"threshold_uncertainty_score":0.9899715,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02406353133911482,"score_gpt":0.3131442406647796,"score_spread":0.2890807093256648,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}