{"id":"W2899462292","doi":"10.1038/s41416-018-0230-7","title":"Tumour budding is associated with the mesenchymal colon cancer subtype and RAS/RAF mutations: a study of 1320 colorectal cancers with Consensus Molecular Subgroup (CMS) data","year":2018,"lang":"en","type":"article","venue":"British Journal of Cancer","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Innovatiefonds Zorgverzekeraars; KWF Kankerbestrijding; ZonMw; Mach-Gaensslen Foundation of Canada; New York Stem Cell Foundation","keywords":"KRAS; Colorectal cancer; Tumor budding; Budding; Pathology; Cancer research; Biology; Epithelial–mesenchymal transition; Phenotype; Oncology; Tissue microarray; Immunohistochemistry; Medicine; Cancer; Internal medicine; Gene; Metastasis; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004462545,0.0002577738,0.0004259319,0.001345175,0.0005030145,0.0004765311,0.0003487412,0.0003250981,0.00158357],"category_scores_gemma":[0.001384168,0.0003187788,0.0004071578,0.001541877,0.0003138611,0.0001793538,0.000843655,0.0002522716,0.0004105829],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006331239,"about_ca_system_score_gemma":0.0005869287,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01747162,"about_ca_topic_score_gemma":0.03052789,"domain_scores_codex":[0.9995328,0.00004129038,0.00006148282,0.0001768038,0.0001110492,0.00007660891],"domain_scores_gemma":[0.9988794,0.0001158141,0.0003757552,0.0001798677,0.0001833525,0.0002657892],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002923,0.00001398148,0.9973025,0.00001428438,0.0000584756,0.00008962775,0.00007117671,0.00002462106,0.001149788,0.000006334051,0.0001009881,0.0008758568],"study_design_scores_gemma":[0.00001344199,0.00007546435,0.9989856,0.000002800984,0.00002614425,0.0003706785,0.0001030679,0.000103059,0.0001323668,0.000004433184,0.0001801725,0.000002842663],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993179,0.0000694497,0.0000259045,0.000005845789,7.354613e-7,0.000007782422,0.0004711634,0.000003159376,0.00009805697],"genre_scores_gemma":[0.9979333,0.00004164946,0.00008892839,0.00000961873,0.000002806692,0.00001265295,0.001780839,0.000004181492,0.0001260905],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01747162,"threshold_uncertainty_score":0.03473985,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02406353133911482,"score_gpt":0.3131442406647796,"score_spread":0.2890807093256648,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}