{"id":"W2899485458","doi":"10.3390/md16110431","title":"Fishing for Targets of Alien Metabolites: A Novel Peroxisome Proliferator-Activated Receptor (PPAR) Agonist from a Marine Pest","year":2018,"lang":"en","type":"article","venue":"Marine Drugs","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Ministero dell’Istruzione, dell’Università e della Ricerca; University of Texas Southwestern Medical Center","keywords":"Agonist; Peroxisome proliferator-activated receptor; Receptor; Peroxisome proliferator-activated receptor alpha; Peroxisome; Pharmacology; Biology; Chemistry; Biochemistry; Nuclear receptor; Transcription factor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003505743,0.0005358751,0.0006555439,0.0001441658,0.0002298905,0.00009517082,0.0005957466,0.0003895598,0.0005286903],"category_scores_gemma":[0.0005179573,0.0005136331,0.000269163,0.0003371275,0.0003028276,0.00003731404,0.0008054444,0.0002392927,0.00002709013],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007057293,"about_ca_system_score_gemma":0.0002294852,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009604134,"about_ca_topic_score_gemma":0.0002079619,"domain_scores_codex":[0.997223,0.00009233526,0.000692229,0.0009664972,0.0003290313,0.0006969472],"domain_scores_gemma":[0.9979554,0.00007120155,0.0003977609,0.0007840483,0.000531662,0.0002599022],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001022037,0.0004024479,0.0174804,0.00006274775,0.0004007355,4.491682e-7,0.0003219708,0.000003458144,0.974668,0.00005651746,0.00322994,0.002351263],"study_design_scores_gemma":[0.002066086,0.0005151013,0.00166752,0.00002594417,0.00006463737,0.000004082674,0.0001532923,0.0001115431,0.8652073,0.000100535,0.129574,0.0005099653],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943154,0.0001141667,0.000706905,0.0005751455,0.0005937923,0.0008975778,0.0007643161,0.00008328264,0.001949354],"genre_scores_gemma":[0.980624,0.00006914853,0.01282946,0.0004038055,0.001625853,0.0002931051,0.00296797,0.0001397535,0.001046916],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1263441,"threshold_uncertainty_score":0.9997315,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01088318918606947,"score_gpt":0.2469179087848573,"score_spread":0.2360347195987878,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}