{"id":"W2899510731","doi":"10.15698/mic2018.11.656","title":"A chemical genetic screen reveals a role for proteostasis in capsule and biofilm formation by Cryptococcus neoformans","year":2018,"lang":"en","type":"article","venue":"Microbial Cell","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Cryptococcus neoformans; Proteasome; Biofilm; Proteostasis; Virulence; Microbiology; Biology; Proteasome inhibitor; Antifungal drug; Virulence factor; Cell biology; Biochemistry; Genetics; Candida albicans; Gene; Bacteria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001501841,0.0004014958,0.0002176309,0.0004046784,0.0002302254,0.000282857,0.0002397282,0.0003017629,0.001082484],"category_scores_gemma":[0.0001773865,0.0001272772,0.0002733198,0.0003192797,0.0002443497,0.0001105572,0.0002053512,0.0002876886,0.0002340729],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004817909,"about_ca_system_score_gemma":0.0004811486,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002939065,"about_ca_topic_score_gemma":0.006391248,"domain_scores_codex":[0.999849,0.00001789842,0.00001281589,0.00002128929,0.00006777921,0.00003113088],"domain_scores_gemma":[0.9998735,0.00002590563,0.00004036476,0.00001345525,0.00001576006,0.00003100711],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001240549,0.00006850556,0.0003542481,0.00002060351,0.000008846347,0.0001274105,0.000004470388,0.00009493121,0.9975461,0.0001054168,0.00006082461,0.001484641],"study_design_scores_gemma":[0.00001886123,0.0004208205,0.006981416,0.000006146936,0.0000288023,0.0005073951,0.00002357045,0.0007647164,0.9899051,0.00008497991,0.001251409,0.000006799744],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898248,0.001023147,0.003556112,0.0003167701,0.000034361,0.00009973406,0.002216603,0.0001187404,0.002809685],"genre_scores_gemma":[0.9932852,0.0006643868,0.003015616,0.0000855564,0.000005951435,0.00002139877,0.001050237,0.00001777295,0.001853991],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002939065,"threshold_uncertainty_score":0.005843937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00898764192271845,"score_gpt":0.2381562364300256,"score_spread":0.2291685945073071,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}