{"id":"W2899510731","doi":"10.15698/mic2018.11.656","title":"A chemical genetic screen reveals a role for proteostasis in capsule and biofilm formation by Cryptococcus neoformans","year":2018,"lang":"en","type":"article","venue":"Microbial Cell","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Cryptococcus neoformans; Proteasome; Biofilm; Proteostasis; Virulence; Microbiology; Biology; Proteasome inhibitor; Antifungal drug; Virulence factor; Cell biology; Biochemistry; Genetics; Candida albicans; Gene; Bacteria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000864301,0.00009768495,0.0001696126,0.00006416917,0.00009000978,0.00001697978,0.0000284121,0.00007526809,0.00003165856],"category_scores_gemma":[0.00001948347,0.0000851217,0.00003833096,0.0001028355,0.00006887368,0.00005717615,0.00003293201,0.0000702956,0.00002285852],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004800826,"about_ca_system_score_gemma":0.00001686883,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001800265,"about_ca_topic_score_gemma":0.00005472673,"domain_scores_codex":[0.9993917,0.00001026041,0.0001958127,0.000144988,0.00004200132,0.0002152722],"domain_scores_gemma":[0.9997354,0.00001059975,0.00004150876,0.00009223356,0.00007037313,0.00004993439],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009031512,0.00007720942,0.0006460945,0.0001116222,0.000007467816,5.977245e-7,0.0005028103,1.200182e-7,0.9715614,0.00000261912,0.02538962,0.001610158],"study_design_scores_gemma":[0.002054044,0.0005335464,0.001735938,0.00006518897,0.00003980741,0.00002348987,0.0001449488,0.0002386519,0.9652175,0.00004328339,0.02977026,0.0001332903],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960947,0.0003808539,0.0005143429,0.0002507791,0.00003212829,0.001232861,0.000086115,0.00002157577,0.001386627],"genre_scores_gemma":[0.9941894,0.00005078152,0.004664861,0.0002689543,0.0001510234,0.0001352096,0.00005314103,0.00001340255,0.0004732315],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006343815,"threshold_uncertainty_score":0.3471162,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00898764192271845,"score_gpt":0.2381562364300256,"score_spread":0.2291685945073071,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}