{"id":"W2899519336","doi":"10.1002/celc.201800985","title":"Electrochemical Detection of Isoform‐Specific Interaction between Apolipoprotein E and Amyloid‐β","year":2018,"lang":"en","type":"article","venue":"ChemElectroChem","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"The Scarborough Hospital; University of Toronto","funders":"University of Toronto Scarborough; Canada Research Chairs; Canada Foundation for Innovation","keywords":"Apolipoprotein E; Gene isoform; Chemistry; Surface plasmon resonance; Cyclic voltammetry; Amyloid (mycology); Amyloid precursor protein; Biophysics; Apolipoprotein B; Peptide; Biochemistry; Alzheimer's disease; Cholesterol; Electrochemistry; Internal medicine; Nanotechnology; Biology; Materials science; Medicine; Disease; Nanoparticle; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005271112,0.0005088867,0.00029225,0.0003601469,0.0001792305,0.0003073452,0.0005790253,0.001099739,0.0008038733],"category_scores_gemma":[0.001139841,0.0002223557,0.0001815545,0.0004196905,0.0002148232,0.0003082731,0.0003503863,0.0005662075,0.0002574624],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001957969,"about_ca_system_score_gemma":0.0001412993,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004315916,"about_ca_topic_score_gemma":0.0005567547,"domain_scores_codex":[0.9994729,0.0001815921,0.00002523453,0.0001272346,0.0001452726,0.00004777446],"domain_scores_gemma":[0.9996445,0.0001988157,0.00004283349,0.00001720653,0.00007320469,0.00002354552],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004902771,0.0000422443,0.0006057628,0.00007365218,0.00001454623,0.00006802359,0.00004022408,0.00009493653,0.9945214,0.00008901628,0.00009309061,0.004307961],"study_design_scores_gemma":[0.00001703639,0.0004141775,0.005414584,0.00001829699,0.00003447379,0.0005033116,0.0001513614,0.008296176,0.9831728,0.0001961392,0.001762948,0.00001883931],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9167351,0.005017612,0.073148,0.0004353519,0.000286293,0.00008446791,0.0004167823,0.0003340414,0.003542467],"genre_scores_gemma":[0.9552042,0.002657094,0.03829767,0.0003696212,0.00005599525,0.0001333284,0.0002477199,0.00001358685,0.003020774],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001099739,"threshold_uncertainty_score":0.00278765,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02118297361098013,"score_gpt":0.3013405411346069,"score_spread":0.2801575675236267,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}