{"id":"W2899531960","doi":"10.1161/circ.132.suppl_3.18897","title":"Abstract 18897: Extracellular Signal-related Kinase Signaling and Smooth Muscle Cell Contractile Gene Expression are Uniformly Enhanced in the Aortic Root and Ascending Aorta in Marfan Syndrome","year":2015,"lang":"en","type":"article","venue":"Circulation","topic":"Connective tissue disorders research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trojan Technologies (Canada)","funders":"","keywords":"Myocardin; Medicine; Marfan syndrome; Ascending aorta; MAPK/ERK pathway; Signal transduction; Aorta; Aortic aneurysm; SMAD; Gene expression; Kinase; Internal medicine; Endocrinology; Cell biology; Biology; Gene; Receptor; Biochemistry; Serum response factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000143099,0.0003768236,0.0002698936,0.000437947,0.0001084127,0.000170722,0.0001063777,0.0003077498,0.003478555],"category_scores_gemma":[0.0002009555,0.0001737909,0.0001882497,0.000119215,0.000243988,0.000109491,0.0001603029,0.000345485,0.000478398],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009758793,"about_ca_system_score_gemma":0.00006961996,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001631167,"about_ca_topic_score_gemma":0.0001569761,"domain_scores_codex":[0.9998554,0.00001994089,0.0000137325,0.00004555217,0.00004864594,0.00001670821],"domain_scores_gemma":[0.9998516,0.00002668009,0.00005967067,0.000009646094,0.00001219547,0.00004023394],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006517383,0.00006440489,0.02030208,0.00008444124,0.00002985803,0.002934637,0.00008261475,0.00002933248,0.9709828,0.00008078422,0.0001683826,0.004588829],"study_design_scores_gemma":[0.0001497928,0.001475176,0.7831224,0.00003979449,0.00009672666,0.05392956,0.0001836632,0.0005894738,0.1574897,0.0001523663,0.002758511,0.00001291812],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988645,0.0003435222,0.0002611352,0.00004428204,0.000007173745,0.000003501476,0.0001339967,0.00001693012,0.0003250958],"genre_scores_gemma":[0.9976572,0.0002528666,0.0007906908,0.00004440692,0.00002693703,0.00001328242,0.00028982,0.000008427767,0.0009164161],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003478555,"threshold_uncertainty_score":0.01163691,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01951885066992726,"score_gpt":0.2669802682736501,"score_spread":0.2474614176037228,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}