{"id":"W2899537750","doi":"10.1093/annonc/mdy470","title":"Identification and validation of novel microenvironment-based immune molecular subgroups of head and neck squamous cell carcinoma: implications for immunotherapy","year":2018,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Ferroptosis and cancer prognosis","field":"Medicine","cited_by":308,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; Ontario Institute for Cancer Research","funders":"Overseas Expertise Introduction Project for Discipline Innovation; National Natural Science Foundation of China","keywords":"Immune system; Head and neck squamous-cell carcinoma; Immunotherapy; Tumor microenvironment; Medicine; Cancer research; Stromal cell; Immunology; Cancer; Biology; Head and neck cancer; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002063271,0.00007611111,0.0002855106,0.00008098117,0.00003127195,0.000002428298,0.00005188222,0.00008194726,0.00001123821],"category_scores_gemma":[0.00002164565,0.00007490571,0.00006449877,0.00007571191,0.0002482511,0.00003232377,0.00001507755,0.00003101056,2.402288e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001544258,"about_ca_system_score_gemma":0.00005988161,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009423703,"about_ca_topic_score_gemma":0.000004580209,"domain_scores_codex":[0.9992554,0.00002474859,0.0003930361,0.0001629137,0.00005950595,0.0001044309],"domain_scores_gemma":[0.9991199,0.00006420759,0.0003428418,0.0002225108,0.0002190002,0.00003152158],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004067598,0.0007512157,0.02448644,0.0001820003,0.00002394041,6.660515e-8,0.0001841723,0.000003073427,0.9666137,0.0001797047,0.00009167645,0.007077261],"study_design_scores_gemma":[0.002494581,0.002997409,0.2820895,0.00001373632,0.00005697711,0.000002277457,0.00004066169,0.00007214283,0.7115674,0.00005270535,0.0005726059,0.00003995631],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906424,0.002035016,0.003777436,0.002889411,0.00002703015,0.0004925317,0.00005756146,0.000003533556,0.00007509564],"genre_scores_gemma":[0.9974723,0.0002170527,0.001912743,0.0002418985,0.00001672644,0.00006701244,0.00004497306,0.0000125209,0.00001480757],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2576031,"threshold_uncertainty_score":0.3054566,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04841772764887307,"score_gpt":0.3440505060970712,"score_spread":0.2956327784481981,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}