{"id":"W2899564417","doi":"10.21037/tgh.2018.10.16","title":"Treatment of advanced hepatocellular carcinoma: immunotherapy from checkpoint blockade to potential of cellular treatment","year":2018,"lang":"en","type":"review","venue":"Translational Gastroenterology and Hepatology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Health and Medical Research Fund; Terry Fox Foundation","keywords":"Medicine; Sorafenib; Nivolumab; Immunotherapy; Immunosuppression; Immune checkpoint; Hepatocellular carcinoma; Oncology; Immune system; Immunology; Internal medicine; Cancer research","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004196681,0.0003274122,0.0004515994,0.0005797416,0.0002080312,0.0007337281,0.0002863445,0.0004345019,0.001867725],"category_scores_gemma":[0.0002519738,0.0001008716,0.0003582233,0.0003357487,0.0004294238,0.0008563481,0.0007869675,0.001648244,0.0005094908],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005182343,"about_ca_system_score_gemma":0.0004508411,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002444865,"about_ca_topic_score_gemma":0.000697191,"domain_scores_codex":[0.9998657,0.00003519659,0.000008680443,0.00001945229,0.00004147567,0.00002949062],"domain_scores_gemma":[0.9999309,0.00001558773,0.00001170603,0.000004931749,0.00001949771,0.00001734702],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005724506,0.0004956699,0.00154856,0.003400067,0.0001143846,0.0004633813,0.0001811249,0.001230422,0.03614138,0.01873068,0.02199433,0.9151275],"study_design_scores_gemma":[0.0005899918,0.00429831,0.008062659,0.002475139,0.0002941802,0.004449372,0.0003291747,0.004003054,0.02580442,0.03261108,0.9169946,0.00008792868],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0173586,0.9557804,0.006329024,0.01080949,0.001183272,0.00007342184,0.00007495168,0.00009588149,0.008295],"genre_scores_gemma":[0.2154335,0.7608479,0.006720476,0.006615374,0.003008513,0.0001883526,0.0003051176,0.00002566719,0.006855104],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001867725,"threshold_uncertainty_score":0.006248116,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02203825477420741,"score_gpt":0.2627538009921815,"score_spread":0.2407155462179741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}