{"id":"W2899591453","doi":"10.1016/j.celrep.2018.09.071","title":"Shiga Toxin/Lipopolysaccharide Activates Caspase-4 and Gasdermin D to Trigger Mitochondrial Reactive Oxygen Species Upstream of the NLRP3 Inflammasome","year":2018,"lang":"en","type":"article","venue":"Cell Reports","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":189,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Agency of Canada; University of Toronto; University of Calgary","funders":"Libin Cardiovascular Institute, University of Calgary; Kidney Foundation of Canada; Canadian Institutes of Health Research; Alberta Innovates - Health Solutions","keywords":"Inflammasome; Reactive oxygen species; Lipopolysaccharide; Caspase 1; Microbiology; Upstream (networking); Toxin; Chemistry; Mitochondrial ROS; Microbial toxins; Cell biology; Biology; Biochemistry; Receptor; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001342529,0.0002123134,0.0002234125,0.00005584965,0.0001418869,0.0000283481,0.0001699504,0.0001592233,0.000054481],"category_scores_gemma":[0.0002414098,0.0001605341,0.0001307516,0.0001063435,0.0002092294,0.00001152616,0.0002431407,0.00009906142,0.000005634693],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001599079,"about_ca_system_score_gemma":0.0001205491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009793355,"about_ca_topic_score_gemma":0.0001124633,"domain_scores_codex":[0.9986984,0.00004898159,0.0003840027,0.0004287634,0.0001530916,0.0002867409],"domain_scores_gemma":[0.9987643,0.00002023788,0.0002837609,0.0006945939,0.0001554068,0.00008173525],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000148108,0.00004801683,0.002977639,0.00001360353,0.00004511044,0.00002234594,0.000343138,0.00000258979,0.9924948,0.00001679488,0.003322741,0.0005651229],"study_design_scores_gemma":[0.0002891564,0.0002189699,0.005449081,0.0000191716,0.00003102077,0.00007180938,0.0004016235,8.273008e-7,0.9401102,0.000123267,0.05309214,0.0001927162],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917839,0.0001892496,0.00002277219,0.0002220127,0.0005815424,0.0003851191,0.000008127497,0.000009661269,0.006797654],"genre_scores_gemma":[0.992425,0.00005130565,0.00012217,0.0001630742,0.0004793667,0.00002517479,0.00002308548,0.00002775951,0.006683106],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05238458,"threshold_uncertainty_score":0.6546391,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005887387887454754,"score_gpt":0.2119747049639712,"score_spread":0.2060873170765165,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}