{"id":"W2899591453","doi":"10.1016/j.celrep.2018.09.071","title":"Shiga Toxin/Lipopolysaccharide Activates Caspase-4 and Gasdermin D to Trigger Mitochondrial Reactive Oxygen Species Upstream of the NLRP3 Inflammasome","year":2018,"lang":"en","type":"article","venue":"Cell Reports","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":189,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Agency of Canada; University of Toronto; University of Calgary","funders":"Libin Cardiovascular Institute, University of Calgary; Kidney Foundation of Canada; Canadian Institutes of Health Research; Alberta Innovates - Health Solutions","keywords":"Inflammasome; Reactive oxygen species; Lipopolysaccharide; Caspase 1; Microbiology; Upstream (networking); Toxin; Chemistry; Mitochondrial ROS; Microbial toxins; Cell biology; Biology; Biochemistry; Receptor; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001927875,0.0004706691,0.0001910446,0.0002372014,0.0001062796,0.0002774365,0.00012385,0.0003896507,0.001821266],"category_scores_gemma":[0.0001226607,0.0001254188,0.0004460929,0.0001674427,0.0002877237,0.0003548126,0.0003679065,0.0004918585,0.0004607317],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003469568,"about_ca_system_score_gemma":0.0002072862,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000198725,"about_ca_topic_score_gemma":0.0002461237,"domain_scores_codex":[0.9998121,0.00004758715,0.0000240708,0.00002946857,0.00003778909,0.00004906145],"domain_scores_gemma":[0.9998879,0.00001130655,0.00004211678,0.00001579584,0.0000142763,0.00002851431],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002188154,0.00002832213,0.0004460852,0.00006147571,0.00001036271,0.0002124705,0.00001324294,0.00004382018,0.9977334,0.0001497513,0.00004768512,0.0010346],"study_design_scores_gemma":[0.0001135439,0.0006357816,0.01899409,0.00001938474,0.00002676911,0.001194368,0.00009849164,0.0008703441,0.9739508,0.0005266684,0.003559921,0.00000986816],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9833916,0.005058627,0.008498521,0.0003911635,0.0001158471,0.00006452283,0.0003189964,0.000124034,0.002036674],"genre_scores_gemma":[0.9928539,0.001962089,0.00277211,0.0001680485,0.00001748314,0.00004561927,0.0003749967,0.00001141214,0.00179429],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001821266,"threshold_uncertainty_score":0.006092787,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005887387887454754,"score_gpt":0.2119747049639712,"score_spread":0.2060873170765165,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}