{"id":"W2899593301","doi":"10.3390/v10110610","title":"Combination Therapy with Oseltamivir and Favipiravir Delays Mortality but Does Not Prevent Oseltamivir Resistance in Immunodeficient Mice Infected with Pandemic A(H1N1) Influenza Virus","year":2018,"lang":"en","type":"article","venue":"Viruses","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Wilfrid Laurier University; Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Favipiravir; Oseltamivir; Virology; Medicine; Neuraminidase inhibitor; Neuraminidase; Virus; Antiviral drug; Combination therapy; Influenza A virus; Regimen; Viral shedding; Pandemic; Pharmacology; Internal medicine; Coronavirus disease 2019 (COVID-19)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008368966,0.0005098768,0.0006951175,0.0003910794,0.000358752,0.00009872277,0.0002248451,0.0001762551,0.00003691117],"category_scores_gemma":[0.0002741801,0.0003155689,0.00005601528,0.0007659761,0.001135014,0.0004701667,0.0001521892,0.0005452828,0.0000437111],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000308932,"about_ca_system_score_gemma":0.0002705994,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002971171,"about_ca_topic_score_gemma":0.00938576,"domain_scores_codex":[0.9965826,0.0002943003,0.0006399559,0.0007767592,0.0009643688,0.0007420733],"domain_scores_gemma":[0.998035,0.0002738333,0.0002839177,0.0006987625,0.0005480061,0.0001605333],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007263232,0.001097403,0.585893,0.0002121211,0.0004426042,0.00005840122,0.002536375,0.000008892534,0.4003263,0.000354022,0.00004149684,0.001766108],"study_design_scores_gemma":[0.00725088,0.001785213,0.7702748,0.0006169488,0.0000968259,0.00001640845,0.000303433,0.00004028921,0.2126487,0.0001093839,0.00636496,0.0004921604],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940301,0.003008455,0.0000521598,0.00009241585,0.00006233083,0.001633221,0.0001198731,0.0002062925,0.0007951947],"genre_scores_gemma":[0.9946865,0.001777647,0.0003201596,0.002522657,0.00007700197,0.0002761699,0.00001194189,0.00007175547,0.0002561653],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1876776,"threshold_uncertainty_score":0.9999297,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07468606115009198,"score_gpt":0.3639109814492428,"score_spread":0.2892249202991508,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}