{"id":"W2899680415","doi":"10.1038/s41598-018-34891-w","title":"Cyclosporine A binding to COX-2 reveals a novel signaling pathway that activates the IRE1α unfolded protein response sensor","year":2018,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of Alberta","funders":"Fondo de Financiamiento de Centros de Investigación en Áreas Prioritarias; Canadian Institutes of Health Research; Government of Canada","keywords":"Unfolded protein response; Signal transduction; Cell biology; Endoplasmic reticulum; Chemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008041831,0.0002461253,0.0001314315,0.0001139307,0.0001946635,0.0002287545,0.000140142,0.000200206,0.001503133],"category_scores_gemma":[0.00006896099,0.00009646176,0.0002564447,0.0001142988,0.0001350845,0.0001170448,0.00009823345,0.0004125993,0.0003255032],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003431443,"about_ca_system_score_gemma":0.0002070233,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008493695,"about_ca_topic_score_gemma":0.001460458,"domain_scores_codex":[0.9999278,0.00001119079,0.000002848583,0.00001652993,0.00002064963,0.00002099527],"domain_scores_gemma":[0.9999526,0.000008476807,0.00001346635,0.000004574709,0.000004344742,0.00001664881],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001366521,0.00002640578,0.0004752839,0.00001903547,0.000008091493,0.00007353242,0.000006033692,0.0000737485,0.9985828,0.0001011091,0.00003117097,0.00046616],"study_design_scores_gemma":[0.00002663697,0.000199141,0.01608104,0.000004323242,0.00002104405,0.0004213229,0.00002797959,0.002573336,0.9785138,0.00008284208,0.002041946,0.000006663341],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950224,0.0009722577,0.002542091,0.0001037093,0.00002559453,0.000008368964,0.0001336063,0.00002771617,0.001164272],"genre_scores_gemma":[0.9961743,0.0006088007,0.001627948,0.00006614916,0.00001173246,0.000007724011,0.0003654626,0.000006983789,0.001130938],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001503133,"threshold_uncertainty_score":0.005028486,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01719986132444929,"score_gpt":0.2583553815765323,"score_spread":0.241155520252083,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}