{"id":"W2899683507","doi":"10.1039/c8ob02453g","title":"Covalent capture of OGT's active site using engineered human-<i>E. coli</i>chimera and intrastrand DNA cross-links","year":2018,"lang":"en","type":"article","venue":"Organic & Biomolecular Chemistry","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Covalent bond; Chimera (genetics); DNA; Nanotechnology; Computational biology; Combinatorial chemistry; Stereochemistry; Biophysics; Biochemistry; Gene; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001817937,0.0003450521,0.0002088568,0.00008663619,0.00008740751,0.0003631192,0.0003158031,0.000428711,0.0005022295],"category_scores_gemma":[0.0001684116,0.0001275125,0.0002651132,0.000171071,0.0002304724,0.0001757077,0.0002747036,0.0006048042,0.000213408],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003681831,"about_ca_system_score_gemma":0.0001668896,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007207989,"about_ca_topic_score_gemma":0.0006630844,"domain_scores_codex":[0.9998259,0.00002299079,0.00001363867,0.00004776249,0.00004774637,0.00004199894],"domain_scores_gemma":[0.9998538,0.00002313471,0.00006007329,0.00001987179,0.00001271324,0.00003027625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008578507,0.00002770305,0.0002065781,0.00001681171,0.000007921433,0.00004222463,0.00001199382,0.0001360673,0.9988477,0.00008799075,0.00001872431,0.0005104692],"study_design_scores_gemma":[0.000003442336,0.00006990974,0.0005089155,0.000001764963,0.000006501014,0.0001041965,0.000009677646,0.0004981248,0.9977354,0.00000808357,0.001051372,0.00000248839],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994653,0.0003841377,0.004034228,0.00005412033,0.00002065359,0.00001760104,0.0001598145,0.00005157475,0.0006248427],"genre_scores_gemma":[0.9942917,0.0002310181,0.003571353,0.00004617107,0.000002594079,0.00001004274,0.0004574294,0.00003127155,0.001358495],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007207989,"threshold_uncertainty_score":0.002671301,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006401270981054961,"score_gpt":0.2688447814378831,"score_spread":0.2624435104568281,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}