{"id":"W2899690379","doi":"10.1093/neuonc/noy148.1121","title":"TMOD-08. GROWTH IMPAIRMENT UNDER CONDITIONS FAVORING MITOCHONDRIAL OXIDATIVE METABOLISM IN A YEAST MODEL OF CANCER-ASSOCIATED ISOCITRATE DEHYDROGENASE MUTATION","year":2018,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Microbial Metabolic Engineering and Bioproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"","keywords":"Isocitrate dehydrogenase; IDH1; Biology; IDH2; Mutant; Biochemistry; Saccharomyces cerevisiae; Isocitrate lyase; Wild type; Yeast; Molecular biology; Gene; Metabolism; Enzyme; Glyoxylate cycle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002125419,0.0006924622,0.0007227507,0.000467169,0.0003078687,0.0005366627,0.001011131,0.0007766936,0.004684179],"category_scores_gemma":[0.0001642677,0.0002134158,0.0006425186,0.0005754119,0.0003279302,0.0002130612,0.0005176475,0.001276169,0.002180564],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006197543,"about_ca_system_score_gemma":0.0007038568,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001923511,"about_ca_topic_score_gemma":0.001891426,"domain_scores_codex":[0.9996189,0.00006425441,0.00006211878,0.00008687505,0.00009652595,0.00007130381],"domain_scores_gemma":[0.99977,0.00002669476,0.00004178724,0.00003838506,0.00002925012,0.0000939023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001148605,0.0005602249,0.0002957399,0.0001151749,0.00001315603,0.0002564314,0.0000419454,0.0002605723,0.9914348,0.0004547101,0.0007222773,0.004696466],"study_design_scores_gemma":[0.0002656231,0.002963281,0.002175179,0.00002094426,0.00002948307,0.0005285781,0.00006883674,0.001973265,0.9770434,0.0001377408,0.01477534,0.00001821711],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9593726,0.001611392,0.009548537,0.0006513449,0.0004257062,0.0006080401,0.01663975,0.001470509,0.009672173],"genre_scores_gemma":[0.9364835,0.001295854,0.01702399,0.0002608656,0.00003500424,0.001061259,0.02187498,0.0003939004,0.02157056],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004684179,"threshold_uncertainty_score":0.01567012,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01281800711716828,"score_gpt":0.2763747991311301,"score_spread":0.2635567920139618,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}