{"id":"W2899709800","doi":"10.1186/s12885-018-4903-7","title":"GPNMB methylation: a new marker of potentially carcinogenic colon lesions","year":2018,"lang":"en","type":"article","venue":"BMC Cancer","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"National Institute on Minority Health and Health Disparities; National Institutes of Health","keywords":"Methylation; Colorectal cancer; DNA methylation; Surgical oncology; Immunohistochemistry; Epigenetics; Tissue microarray; Cancer research; Medicine; Adenoma; Pathology; CpG site; Colorectal adenoma; Cancer; Biology; Internal medicine; Gene expression; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000127107,0.000090268,0.0001043929,0.00003433775,0.00005411303,0.000008715067,0.0001027928,0.0001133071,0.0002405443],"category_scores_gemma":[0.00005144496,0.00008760237,0.00008574025,0.0001037647,0.0000620257,0.0000024283,0.00005620063,0.00003310663,0.000009149271],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001699179,"about_ca_system_score_gemma":0.0003259557,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003990672,"about_ca_topic_score_gemma":0.001839348,"domain_scores_codex":[0.9992929,0.00004727028,0.0001835963,0.0002167696,0.0001217995,0.0001377315],"domain_scores_gemma":[0.9993973,0.000009965524,0.0001006484,0.0002535789,0.0001678666,0.00007058276],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001053021,0.0000168883,0.02079292,0.00001095718,0.00003323653,1.632984e-7,0.00004660003,0.0001121307,0.9662702,0.00005281804,0.002259999,0.01029877],"study_design_scores_gemma":[0.0004610128,0.0002151317,0.08808055,0.00001328919,0.00004372433,5.871474e-7,0.00001247016,0.00006970453,0.8522561,0.0002795653,0.0584381,0.0001298181],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9688687,0.007472611,0.02059256,0.00009184461,0.000354077,0.0001552308,0.00002145153,0.000006591117,0.00243698],"genre_scores_gemma":[0.9904042,0.000386069,0.004346058,0.00006265186,0.0007606427,0.00001252434,0.00003394642,0.00001662959,0.003977254],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1140142,"threshold_uncertainty_score":0.3572321,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02776706594723683,"score_gpt":0.3077314697841633,"score_spread":0.2799644038369264,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}