{"id":"W2899765159","doi":"10.2196/11441","title":"The Safety, Tolerability, and Effects on the Systemic Inflammatory Response and Renal Function of the Human Chorionic Gonadotropin Hormone-Derivative EA-230 Following On-Pump Cardiac Surgery (The EASI Study): Protocol for a Randomized, Double-Blind, Placebo-Controlled Phase 2 Study","year":2018,"lang":"en","type":"article","venue":"JMIR Research Protocols","topic":"Acute Kidney Injury Research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Tolerability; Cardiac surgery; Cardiopulmonary bypass; Internal medicine; Placebo; Anesthesia; Surgery; Adverse effect; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01575661,0.004549101,0.005667817,0.001174935,0.002004897,0.001682943,0.002515293,0.004704338,0.0138966],"category_scores_gemma":[0.008897829,0.001609786,0.002335768,0.001277891,0.002678349,0.002077754,0.0008499374,0.004280393,0.003301078],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001478863,"about_ca_system_score_gemma":0.006279393,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004725023,"about_ca_topic_score_gemma":0.001017403,"domain_scores_codex":[0.9919362,0.00510045,0.0007046291,0.0006625446,0.0007306712,0.0008655347],"domain_scores_gemma":[0.99439,0.0009353194,0.001419204,0.0009116235,0.001035493,0.001308489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.938888,0.0372479,0.0009354464,0.001437107,0.0003584197,0.0001093917,0.0001422046,0.0005579018,0.007901664,0.0003793252,0.002146044,0.009896806],"study_design_scores_gemma":[0.7670781,0.2172605,0.003507901,0.0002204076,0.0003893798,0.00006958774,0.00005844026,0.0005562298,0.002424717,0.0003747276,0.007998013,0.00006203225],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.1401998,0.001255033,0.003948029,0.0004580073,0.000547432,0.8471969,0.003296896,0.0002281062,0.002869637],"genre_scores_gemma":[0.09633646,0.0008813401,0.006702191,0.001001407,0.0003887405,0.891679,0.001307037,0.00003966715,0.001664117],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.01575661,"threshold_uncertainty_score":0.08332992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1349750662379738,"score_gpt":0.5020043504521896,"score_spread":0.3670292842142158,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}