{"id":"W2899768010","doi":"10.1093/neuonc/noz036.198","title":"MEDU-40. MATCHING OF SINGLE CELL TRANSCRIPTOMICS FROM CEREBELLAR DEVELOPMENT IDENTIFIES PUTATIVE SUBGROUP SPECIFIC CELLS OF ORIGIN FOR MEDULLOBLASTOMA","year":2019,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of Calgary; Hospital for Sick Children; University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"Biology; Medulloblastoma; Population; Cerebellum; Lineage markers; Single-cell analysis; Cell sorting; Progenitor cell; Stem cell; Genetics; Cell; Neuroscience","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000175854,0.0002794634,0.0003257953,0.0005062543,0.0004548407,0.0004862211,0.0002204438,0.0003314821,0.004144614],"category_scores_gemma":[0.0002474239,0.0001917863,0.0004297516,0.0003826882,0.0002065203,0.0001503214,0.0003413925,0.0002951988,0.001806416],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004725935,"about_ca_system_score_gemma":0.0004021448,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00258345,"about_ca_topic_score_gemma":0.0113445,"domain_scores_codex":[0.9998023,0.000008514266,0.00000878128,0.00008754477,0.00005401326,0.00003888118],"domain_scores_gemma":[0.9998908,0.00002272004,0.00002584718,0.00001711923,0.00001923085,0.00002433878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001440205,0.00001493116,0.006012452,0.0001183179,0.00002096246,0.0001309299,0.0001274695,0.0002925682,0.9829171,0.0003100205,0.0009177188,0.008993496],"study_design_scores_gemma":[0.00003712493,0.0002452024,0.2294174,0.00005574218,0.0001201517,0.001218613,0.0003035438,0.01032116,0.6920331,0.0008647884,0.06535204,0.00003112984],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9107745,0.002049052,0.02272318,0.0002706063,0.0001049323,0.0001139097,0.05229976,0.002088231,0.009575792],"genre_scores_gemma":[0.8874369,0.0009968147,0.03467591,0.0003544723,0.00003489929,0.0003161155,0.06173155,0.001000787,0.01345253],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004144614,"threshold_uncertainty_score":0.01386511,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01767454300854074,"score_gpt":0.2698232093825114,"score_spread":0.2521486663739706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}