{"id":"W2899768010","doi":"10.1093/neuonc/noz036.198","title":"MEDU-40. MATCHING OF SINGLE CELL TRANSCRIPTOMICS FROM CEREBELLAR DEVELOPMENT IDENTIFIES PUTATIVE SUBGROUP SPECIFIC CELLS OF ORIGIN FOR MEDULLOBLASTOMA","year":2019,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of Calgary; Hospital for Sick Children; University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"Biology; Medulloblastoma; Population; Cerebellum; Lineage markers; Single-cell analysis; Cell sorting; Progenitor cell; Stem cell; Genetics; Cell; Neuroscience","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003041307,0.0002583009,0.0005084275,0.0001389363,0.0000536769,0.00001570717,0.0004258009,0.0003817157,0.00009802214],"category_scores_gemma":[0.00003468709,0.0002776758,0.0001974411,0.0001511858,0.0001351108,0.000008541224,0.0001537176,0.0002169322,0.00002370251],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001369265,"about_ca_system_score_gemma":0.0004959647,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005023276,"about_ca_topic_score_gemma":0.00008868516,"domain_scores_codex":[0.9978067,0.0001978774,0.0006100986,0.0006485271,0.0003077167,0.00042903],"domain_scores_gemma":[0.9986838,0.0001936599,0.0003313404,0.0004268176,0.0002531661,0.0001112694],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009253907,0.0002749962,0.00001853857,0.0001216027,0.0001126381,0.000008585218,0.0009312229,0.0005826176,0.9940817,0.00005769057,0.0006059082,0.00227916],"study_design_scores_gemma":[0.00174658,0.001327922,0.00002304278,0.0000206812,0.0000335406,0.000006144579,0.0005211675,0.00005967081,0.9034704,0.000258992,0.09232476,0.0002071338],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9613215,0.000632452,0.03517428,0.00007389644,0.001017483,0.0009069548,0.0001648676,0.00001269403,0.0006958501],"genre_scores_gemma":[0.9895616,0.0002510207,0.009430294,0.0001273976,0.0001025619,0.00005415119,0.0002214543,0.00007608,0.000175506],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09171885,"threshold_uncertainty_score":0.9999675,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01767454300854074,"score_gpt":0.2698232093825114,"score_spread":0.2521486663739706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}