{"id":"W2899769766","doi":"10.1371/journal.pone.0206920","title":"Miransertib (ARQ 092), an orally-available, selective Akt inhibitor is effective against Leishmania","year":2018,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; ArQule","keywords":"Visceral leishmaniasis; Leishmania; Leishmaniasis; Amastigote; Leishmania donovani; Protein kinase B; Miltefosine; Pharmacology; Cutaneous leishmaniasis; PI3K/AKT/mTOR pathway; Biology; Immunology; Medicine; Phosphorylation; Signal transduction; Parasite hosting; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001501317,0.0003879707,0.0003340218,0.0003017828,0.0001409015,0.0003260311,0.0002287683,0.0003787206,0.002679864],"category_scores_gemma":[0.00007213998,0.0001451366,0.00027045,0.0002270165,0.000184375,0.0001859825,0.0001650603,0.0006665429,0.0007765042],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002942384,"about_ca_system_score_gemma":0.0002312228,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004867071,"about_ca_topic_score_gemma":0.001463294,"domain_scores_codex":[0.9999112,0.00001866852,0.000008066322,0.00001809187,0.00002729918,0.00001660192],"domain_scores_gemma":[0.9999708,0.000003276733,0.000009631809,0.000002314866,0.00000572464,0.000008273109],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001490671,0.000616856,0.0008201233,0.0006577284,0.00008482749,0.0004330705,0.0000306475,0.0006262991,0.9069143,0.0005931355,0.003300503,0.08443183],"study_design_scores_gemma":[0.003745486,0.01857053,0.01779645,0.0001281035,0.000356646,0.009032154,0.00007837294,0.00333798,0.7819647,0.0005005664,0.1644282,0.00006073932],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8600268,0.1057659,0.004731855,0.00194936,0.0003958704,0.0005302395,0.002423775,0.0009923881,0.02318385],"genre_scores_gemma":[0.9601062,0.02299548,0.003326018,0.0005296713,0.0000646119,0.0001209565,0.002840981,0.00002495012,0.009991114],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002679864,"threshold_uncertainty_score":0.008965015,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05211337349675108,"score_gpt":0.2910217470036502,"score_spread":0.2389083735068992,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}