{"id":"W2899769766","doi":"10.1371/journal.pone.0206920","title":"Miransertib (ARQ 092), an orally-available, selective Akt inhibitor is effective against Leishmania","year":2018,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; ArQule","keywords":"Visceral leishmaniasis; Leishmania; Leishmaniasis; Amastigote; Leishmania donovani; Protein kinase B; Miltefosine; Pharmacology; Cutaneous leishmaniasis; PI3K/AKT/mTOR pathway; Biology; Immunology; Medicine; Phosphorylation; Signal transduction; Parasite hosting; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005557612,0.0004483674,0.0009396202,0.0003264082,0.0004396735,0.0000903562,0.0003003083,0.0002217776,0.0008605798],"category_scores_gemma":[0.001019215,0.0003970017,0.0001428469,0.0008487501,0.0005616343,0.000480323,0.0002031747,0.0006604664,0.003693155],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004879857,"about_ca_system_score_gemma":0.0002609535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002064772,"about_ca_topic_score_gemma":0.0003352782,"domain_scores_codex":[0.9960127,0.0002711577,0.0004424694,0.0009774073,0.001321455,0.0009747974],"domain_scores_gemma":[0.9964791,0.0002498866,0.0001345346,0.0008475156,0.001787461,0.0005015354],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003451983,0.01034102,0.1045433,0.0009016396,0.004461965,0.0002400314,0.008250372,1.773437e-7,0.7630028,0.00006295818,0.09717155,0.007572246],"study_design_scores_gemma":[0.004528386,0.008962248,0.06159844,0.001019801,0.0005631076,0.00001415077,0.000507459,0.000431723,0.917773,0.0001559116,0.003808921,0.0006368129],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9549611,0.0005139959,0.0000200327,0.001878893,0.00009335034,0.0024156,0.00004104589,0.0003529859,0.03972305],"genre_scores_gemma":[0.985199,0.0003023973,0.002846619,0.002539921,0.001649319,0.000397927,0.00003826531,0.0001368244,0.006889716],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1547703,"threshold_uncertainty_score":0.9998482,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05211337349675108,"score_gpt":0.2910217470036502,"score_spread":0.2389083735068992,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}