{"id":"W2899846936","doi":"10.2174/0929867325666181105115849","title":"Use of Anticancer Platinum Compounds in Combination Therapies and Challenges in Drug Delivery","year":2018,"lang":"en","type":"review","venue":"Current Medicinal Chemistry","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Science and Technology Department of Henan Province; Program for Jilin University Science and Technology Innovative Research Team; Department of Science and Technology of Jilin Province; Education Department of Jilin Province","keywords":"Drug delivery; Drug; Pharmacology; Dendrimer; Drug resistance; Liposome; Platinum; Nanotechnology; Anticancer drug; Chemistry; Medicine; Materials science; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006104492,0.0005973764,0.001004603,0.001827271,0.0002795935,0.0008192869,0.0006861368,0.0009979721,0.001985656],"category_scores_gemma":[0.0005187285,0.0003426335,0.0004455307,0.001504125,0.0005159788,0.001399085,0.0006227701,0.001718001,0.001135941],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005300796,"about_ca_system_score_gemma":0.0006088286,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005790598,"about_ca_topic_score_gemma":0.001072385,"domain_scores_codex":[0.9997022,0.00005195563,0.00003403852,0.00005861809,0.0001290439,0.00002405415],"domain_scores_gemma":[0.9997757,0.000119324,0.00003371368,0.00000997048,0.00004733088,0.00001392189],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005634246,0.00008787137,0.0001679653,0.01489156,0.0000728926,0.0003966592,0.000128346,0.0006017816,0.007484267,0.009171398,0.01372176,0.9532192],"study_design_scores_gemma":[0.00001236211,0.0001468637,0.000474863,0.0014493,0.00006185341,0.002504747,0.0000512685,0.0002206433,0.002981167,0.001807701,0.9902717,0.00001744722],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000362022,0.9976959,0.000324959,0.0002089825,0.0001293229,0.000005080579,0.000006957419,0.000006355855,0.001260375],"genre_scores_gemma":[0.002322158,0.996087,0.0004553916,0.0001795857,0.0001512185,0.00001014617,0.00001366405,0.000002249527,0.0007786735],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001985656,"threshold_uncertainty_score":0.006642699,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1209955573356354,"score_gpt":0.3297890418943376,"score_spread":0.2087934845587022,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}