{"id":"W2899854850","doi":"10.1101/468306","title":"Biobank-wide association scan identifies risk factors for late-onset Alzheimer’s disease and endophenotypes","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Division of Graduate Education; National Heart, Lung, and Blood Institute; National Institute on Aging; National Center for Advancing Translational Sciences; Medical Research Council; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Centre hospitalier régional universitaire de Lille; Genentech; Erasmus Medisch Centrum; Bundesministerium für Bildung und Forschung; Institut National de la Santé et de la Recherche Médicale; Hjartavernd; Northern California Institute for Research and Education; IXICO; University of Pittsburgh; Northwestern University; Biogen; BioClinica; F. Hoffmann-La Roche; Eisai; University of Wisconsin-Madison; Development of Innovative Strategies for a Transdisciplinary approach to ALZheimer's disease; Georgia Clinical and Translational Science Alliance; University of Pennsylvania; Wellcome Trust; University of Southern California; Université de Lille; Alzheimer's Disease Neuroimaging Initiative; Extendicare Foundation; Wisconsin Alumni Research Foundation; Northwestern Mutual Foundation; Eli Lilly and Company; Bristol-Myers Squibb; Helen Bader Foundation; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Biobank; Endophenotype; Genome-wide association study; Disease; Association (psychology); Genetic association; Cohort; Biology; Psychology; Medicine; Genetics; Cognition; Neuroscience; Single-nucleotide polymorphism; Internal medicine; Gene; Genotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005753126,0.0004938311,0.0008409239,0.001994697,0.0005221803,0.00193419,0.0005590311,0.0006960283,0.005526253],"category_scores_gemma":[0.01163882,0.0004276343,0.0006547219,0.002552534,0.0006164864,0.0007914734,0.001292228,0.000817586,0.001107633],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003096496,"about_ca_system_score_gemma":0.0007939643,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001646727,"about_ca_topic_score_gemma":0.003100086,"domain_scores_codex":[0.997693,0.0008501369,0.0002440587,0.0007696408,0.0003006276,0.0001424302],"domain_scores_gemma":[0.9919761,0.004307026,0.001425001,0.001608894,0.0003483244,0.0003346272],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00158917,0.0001503111,0.8863704,0.0006189033,0.002208584,0.0006470112,0.0005741327,0.003598894,0.02457845,0.003635537,0.026963,0.04906555],"study_design_scores_gemma":[0.0002391977,0.0001381521,0.9293054,0.0001475563,0.0009936085,0.0008493254,0.0003204877,0.0136006,0.009272303,0.0175475,0.02750992,0.00007586034],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8463913,0.002273929,0.05359059,0.002397115,0.0002051936,0.0000790811,0.08941626,0.001877408,0.003769039],"genre_scores_gemma":[0.9027998,0.0006790973,0.04278054,0.000694284,0.0001445349,0.0001719382,0.05008503,0.0003076796,0.002336965],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005753126,"threshold_uncertainty_score":0.03042585,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01549036907614918,"score_gpt":0.2422875152316942,"score_spread":0.226797146155545,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}