{"id":"W2899858004","doi":"10.1093/neuonc/noy148.444","title":"GENE-18. DIVERGENT CLONAL EVOLUTION OF MELANOMA BRAIN METASTASES DURING TREATMENT WITH IMMUNOTHERAPY","year":2018,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Toronto Western Hospital; Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Immunotherapy; Melanoma; CD8; Cancer research; CDKN2A; Immune checkpoint; Tumor microenvironment; Biology; Exome sequencing; Somatic evolution in cancer; Immune system; Medicine; Immunology; Cancer; Gene; Mutation; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001318866,0.0001420635,0.0002465883,0.0003222079,0.0001813169,0.0002367716,0.0001116534,0.0002108825,0.001146558],"category_scores_gemma":[0.000389447,0.00007701806,0.0002056306,0.0003257726,0.0001301586,0.00008912605,0.0001143172,0.0002339368,0.0002827847],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002403885,"about_ca_system_score_gemma":0.0001550203,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006947185,"about_ca_topic_score_gemma":0.001398108,"domain_scores_codex":[0.9998673,0.00001424209,0.000007481131,0.00004221962,0.0000427028,0.00002605152],"domain_scores_gemma":[0.9997947,0.00004298357,0.00006833544,0.00001941155,0.00004293424,0.00003174746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007173713,0.00006300336,0.09636278,0.00009875127,0.00006682706,0.001236746,0.0002333059,0.001064119,0.8714954,0.0002224677,0.0005212578,0.02791806],"study_design_scores_gemma":[0.00004157981,0.0007709896,0.7457131,0.00003035582,0.0001142402,0.008013314,0.0001947336,0.006869873,0.2304397,0.0006626508,0.007130785,0.00001862546],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968544,0.0002488318,0.001077053,0.0000439658,0.000005870784,0.00001852558,0.001012097,0.00003098934,0.0007083517],"genre_scores_gemma":[0.9959449,0.0001088025,0.001620907,0.00005217488,0.000004497171,0.00002476361,0.001532615,0.0000325133,0.0006788262],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001146558,"threshold_uncertainty_score":0.003835618,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02487150958697298,"score_gpt":0.3006407671642806,"score_spread":0.2757692575773076,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}