{"id":"W2899884916","doi":"10.2196/12046","title":"The Japanese Early-Stage Trial of High-Dose Methylcobalamin for Amyotrophic Lateral Sclerosis (JETALS): Protocol for a Randomized Controlled Trial","year":2018,"lang":"en","type":"article","venue":"JMIR Research Protocols","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ministry of Health, Labour and Welfare; Japan Agency for Medical Research and Development","keywords":"Riluzole; Amyotrophic lateral sclerosis; Medicine; Placebo; Clinical endpoint; Randomized controlled trial; Clinical trial; Methylcobalamin; Neurology; Internal medicine; Physical therapy; Disease; Psychiatry; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01925633,0.006649678,0.01062613,0.001360803,0.003328399,0.003247377,0.003016941,0.00570035,0.04029241],"category_scores_gemma":[0.01492977,0.002454998,0.004310329,0.002293747,0.003193809,0.002727904,0.00162251,0.006482635,0.007246003],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004376943,"about_ca_system_score_gemma":0.01313387,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002865891,"about_ca_topic_score_gemma":0.007079908,"domain_scores_codex":[0.9849452,0.009681433,0.001320463,0.001519527,0.001207941,0.001325428],"domain_scores_gemma":[0.9925346,0.001424973,0.001716745,0.001005847,0.001666799,0.001651103],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"not_applicable","study_design_scores_codex":[0.9621933,0.005273379,0.0004999236,0.007967875,0.001667915,0.0001274493,0.0001504012,0.0008597019,0.00149087,0.001419309,0.009326714,0.009023104],"study_design_scores_gemma":[0.9747313,0.01090689,0.001039678,0.0005760707,0.0006938461,0.00002902511,0.00004572932,0.0007793816,0.0002973824,0.0007468251,0.01010763,0.00004631468],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.005809207,0.0008494585,0.001668157,0.0004238898,0.0005159755,0.9869783,0.002076128,0.0001523575,0.001526455],"genre_scores_gemma":[0.007302302,0.0003636873,0.00213713,0.0005027155,0.0001058275,0.9881434,0.000503804,0.00001195426,0.0009292751],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.04029241,"threshold_uncertainty_score":0.1347916,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2160371548710987,"score_gpt":0.5199755742585439,"score_spread":0.3039384193874453,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}