{"id":"W2899927457","doi":"10.3389/fphar.2018.01239","title":"Aqueous Extract of Mori Folium Exerts Bone Protective Effect Through Regulation of Calcium and Redox Homeostasis via PTH/VDR/CaBP and AGEs/RAGE/Nox4/NF-κB Signaling in Diabetic Rats","year":2018,"lang":"en","type":"article","venue":"Frontiers in Pharmacology","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Higher Education Discipline Innovation Project; Ministry of Education, India; National Natural Science Foundation of China","keywords":"Endocrinology; Internal medicine; RANKL; Calcitriol receptor; Chemistry; Osteoprotegerin; Osteocalcin; Sclerostin; Glycation; Receptor; Medicine; Biochemistry; Activator (genetics); Signal transduction; Alkaline phosphatase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009514834,0.0003956289,0.0003576626,0.0005618439,0.0002256155,0.000143415,0.0001149843,0.0002878208,0.0009544934],"category_scores_gemma":[0.00006528223,0.0001247575,0.0003486382,0.000162722,0.0001580025,0.0002247609,0.0001396176,0.0004265521,0.00008211603],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001314018,"about_ca_system_score_gemma":0.0001593624,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006721709,"about_ca_topic_score_gemma":0.001057645,"domain_scores_codex":[0.9999502,0.000005774346,0.000004302739,0.00001095904,0.00001644273,0.00001230141],"domain_scores_gemma":[0.9999471,0.0000028053,0.00002067164,0.000002890921,0.000008816453,0.00001780548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008214682,0.0001595531,0.0006822852,0.000171019,0.00002893656,0.00006655267,0.0000221581,0.00002976698,0.9937622,0.00004553064,0.00004758723,0.004163025],"study_design_scores_gemma":[0.0005003359,0.009875166,0.06683171,0.00009448645,0.0005092174,0.001195181,0.0001969064,0.0009982629,0.9092951,0.0002994274,0.01017435,0.00002978651],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909537,0.006570446,0.001403265,0.0001365674,0.00003205719,0.00002438273,0.0001980223,0.00004122613,0.0006402914],"genre_scores_gemma":[0.9905099,0.00510401,0.00219339,0.0001347065,0.00003535401,0.00003858651,0.000377254,0.00001030466,0.001596384],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009544934,"threshold_uncertainty_score":0.003193021,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007161153561364549,"score_gpt":0.267909194529093,"score_spread":0.2607480409677285,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}