{"id":"W2899936404","doi":"10.1093/neuonc/noy148.1177","title":"CADD-49. IDENTIFICATION AND VALIDATION OF AZOLES AS HK2 INHIBITORS IN GLIOBLASTOMA <i>IN VITRO</i> AND <i>IN VIVO</i>","year":2018,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Eicosanoids and Hypertension Pharmacology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital; Princess Margaret Cancer Centre","funders":"","keywords":"Glioma; Ketoconazole; In vivo; Glycolysis; Apoptosis; Gene knockdown; Chemistry; Cancer research; In vitro; Angiogenesis; Biology; Pharmacology; Biochemistry; Metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002666324,0.0005091784,0.0006789151,0.0007062081,0.0002486079,0.0003621524,0.0003780637,0.0002922077,0.001531804],"category_scores_gemma":[0.0002164439,0.0001705897,0.0004226775,0.0006420696,0.0001666092,0.0001836021,0.0001729727,0.0003805453,0.000505873],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004735583,"about_ca_system_score_gemma":0.0004072207,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002205082,"about_ca_topic_score_gemma":0.004381398,"domain_scores_codex":[0.9998005,0.00003553764,0.00001987363,0.00004211491,0.000063662,0.00003830107],"domain_scores_gemma":[0.9999026,0.00001419273,0.00001742392,0.00000946049,0.00003772234,0.00001869378],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006832295,0.0002767945,0.00124462,0.0002281088,0.00004396565,0.0001505394,0.00002149879,0.0009541973,0.9783518,0.0001384244,0.0006222649,0.01728463],"study_design_scores_gemma":[0.0002306269,0.002512777,0.009164568,0.00002206654,0.0001331918,0.0003207069,0.00002735744,0.002425208,0.9769124,0.00004263647,0.008191557,0.00001693974],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9610412,0.01255596,0.007703543,0.0003628626,0.00009506456,0.0006987469,0.0107685,0.000384291,0.006389815],"genre_scores_gemma":[0.9594475,0.007801297,0.01050677,0.0002404343,0.0000281738,0.0004273266,0.01709103,0.00004859016,0.004408942],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002205082,"threshold_uncertainty_score":0.00512439,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009128024869980739,"score_gpt":0.2774687102528067,"score_spread":0.268340685382826,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}