{"id":"W2899955386","doi":"10.1007/s10549-018-5027-0","title":"CYP2D6 as a treatment decision aid for ER-positive non-metastatic breast cancer patients: a systematic review with accompanying clinical practice guidelines","year":2018,"lang":"en","type":"review","venue":"Breast Cancer Research and Treatment","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Research (Canada); BC Cancer Agency; BC Children's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Tamoxifen; Breast cancer; CYP2D6; Medicine; Oncology; Genotyping; Context (archaeology); Metastatic breast cancer; Critical appraisal; Internal medicine; Gynecology; Cancer; Bioinformatics; Biology; Genotype; Alternative medicine; Pathology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003139514,0.001015398,0.004258037,0.003465503,0.0002737916,0.001464754,0.001289851,0.001576488,0.006006576],"category_scores_gemma":[0.01504758,0.0005817625,0.006725986,0.002970876,0.0003773768,0.001069717,0.0007689163,0.001365555,0.0003783597],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001176416,"about_ca_system_score_gemma":0.003189309,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004400493,"about_ca_topic_score_gemma":0.01741369,"domain_scores_codex":[0.9979754,0.0006463306,0.0007880187,0.0002357626,0.0002946594,0.00005977898],"domain_scores_gemma":[0.9936454,0.00452308,0.001254436,0.00007806116,0.0004270089,0.00007204855],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"systematic_review","study_design_scores_codex":[0.000915942,0.00006300628,0.00136233,0.7351781,0.02068227,0.0001497132,0.0001110623,0.0003294716,0.000368477,0.0006945386,0.01067264,0.2294725],"study_design_scores_gemma":[0.002420857,0.0004298536,0.00663472,0.6575004,0.2168911,0.0008477257,0.0002290314,0.0004097629,0.0004635402,0.001710084,0.1123417,0.0001211776],"study_design_candidate":"systematic_review","study_design_consensus":"systematic_review","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002749041,0.9988029,0.0001036002,0.0003131911,0.00007637839,0.00005177033,0.000203626,0.000004525884,0.0001691337],"genre_scores_gemma":[0.006655123,0.9907986,0.0009962204,0.0009972584,0.0001000086,0.00009333067,0.0002212199,0.00000322875,0.0001350567],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.006006576,"threshold_uncertainty_score":0.02009398,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3907801118929002,"score_gpt":0.6369050860232861,"score_spread":0.2461249741303859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}