{"id":"W2900003524","doi":"10.1093/neuonc/noy148.311","title":"DRES-04. CHARACTERIZATION OF A MODEL OF TEMOZOLOMIDE RESISTANCE IN GLIOBLASTOMA","year":2018,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Temozolomide; MSH6; MLH1; MSH2; Cancer research; Methyltransferase; Downregulation and upregulation; DNA repair; Homologous recombination; Biology; DNA mismatch repair; O-6-methylguanine-DNA methyltransferase; Thiostrepton; Glioblastoma; Gene; Genetics; Methylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001892071,0.0003083704,0.0002951692,0.0003911309,0.0001868834,0.0002430805,0.0004747123,0.0003247252,0.00167999],"category_scores_gemma":[0.0001283069,0.0001464272,0.0003399144,0.0002589414,0.0001586548,0.0001537461,0.0001887098,0.0005868149,0.0005904101],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006550939,"about_ca_system_score_gemma":0.0003267418,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00467269,"about_ca_topic_score_gemma":0.004800076,"domain_scores_codex":[0.9998513,0.00002317727,0.00001608695,0.00002769056,0.00004520293,0.00003646717],"domain_scores_gemma":[0.9999058,0.00001155911,0.00002174089,0.00001502949,0.00001386479,0.00003205964],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006639475,0.00007413648,0.0001817863,0.00001700498,0.000003431948,0.00007601844,0.00001340003,0.0001036936,0.9985502,0.0001250832,0.00007811472,0.0007106172],"study_design_scores_gemma":[0.00004657186,0.001625266,0.007826097,0.000009317676,0.00002136887,0.0007144233,0.00008372764,0.004273823,0.9783117,0.0001106453,0.006966186,0.00001103494],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912493,0.0005899568,0.003756933,0.0001800346,0.00003647603,0.0001068785,0.001786395,0.0001429176,0.002151132],"genre_scores_gemma":[0.9779202,0.0007523806,0.007166125,0.0001339455,0.000007052872,0.0001532074,0.005175992,0.00006286156,0.008628316],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00467269,"threshold_uncertainty_score":0.009290934,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02319652710978198,"score_gpt":0.2934345794895475,"score_spread":0.2702380523797656,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}