{"id":"W2900026479","doi":"10.3389/fncel.2018.00397","title":"Diverse Protein Profiles in CNS Myeloid Cells and CNS Tissue From Lipopolysaccharide- and Vehicle-Injected APPSWE/PS1ΔE9 Transgenic Mice Implicate Cathepsin Z in Alzheimer’s Disease","year":2018,"lang":"en","type":"article","venue":"Frontiers in Cellular Neuroscience","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; Mount Saint Vincent University","funders":"Medical Research Council; VILLUM Center for Bioanalytical Sciences; Sundhed og Sygdom, Det Frie Forskningsråd; Th. Maigaards Eftf. Fru Lily Benthine Lunds Fond af 1.6. 1978; Novo Nordisk Fonden; Frimodt-Heineke Fonden; H. Lundbeck A/S; Grosserer M. Brogaard og Hustrus Mindefond; Syddansk Universitet; Lundbeckfonden","keywords":"Microglia; Neuroinflammation; Genetically modified mouse; Amyloid precursor protein; Inflammation; Cathepsin D; Biology; Neurodegeneration; Immunology; Medicine; Pathology; Transgene; Alzheimer's disease; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007551,0.0003716229,0.0002337834,0.0005290358,0.0001810868,0.0002171625,0.00009770907,0.000226891,0.0007801043],"category_scores_gemma":[0.00008353125,0.0001231041,0.0002351435,0.0002544097,0.0002261584,0.0001531,0.0002095208,0.0004112574,0.0002622143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001449015,"about_ca_system_score_gemma":0.0001311385,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004195795,"about_ca_topic_score_gemma":0.0006645952,"domain_scores_codex":[0.9999149,0.000004280503,0.00001018773,0.00002531949,0.00002080225,0.00002456812],"domain_scores_gemma":[0.9999009,0.000007695068,0.00003505456,0.000008353284,0.00001476109,0.00003320193],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000856179,0.000006252394,0.000501499,0.00001885916,0.000005388934,0.00007307241,0.00002179631,0.000006036184,0.9989455,0.00001322148,0.00001044207,0.0003123138],"study_design_scores_gemma":[0.00002570533,0.0003993214,0.2021208,0.00002626146,0.00008089062,0.003360512,0.0002405794,0.0004136896,0.7905706,0.0002262411,0.00251496,0.00002059777],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966843,0.000844432,0.0008567264,0.00004425349,0.00001523024,0.00001585041,0.001122817,0.00002611511,0.0003902449],"genre_scores_gemma":[0.9907026,0.001528365,0.003154281,0.00009462504,0.00001594977,0.00007453393,0.002457033,0.00002736386,0.00194526],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007801043,"threshold_uncertainty_score":0.00260973,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02623978266377594,"score_gpt":0.2795729063208062,"score_spread":0.2533331236570303,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}