{"id":"W2900052614","doi":"10.1093/ofid/ofy295","title":"Effect of On-Demand Oral Pre-exposure Prophylaxis With Tenofovir/Emtricitabine on Herpes Simplex Virus-1/2 Incidence Among Men Who Have Sex With Men: A Substudy of the ANRS IPERGAY Trial","year":2018,"lang":"en","type":"article","venue":"Open Forum Infectious Diseases","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Gilead Sciences; Bill and Melinda Gates Foundation","keywords":"Medicine; Emtricitabine; Pre-exposure prophylaxis; Incidence (geometry); Placebo; Herpes simplex virus; Men who have sex with men; Population; Tenofovir; Internal medicine; Virology; Viral load; Human immunodeficiency virus (HIV); Virus; Antiretroviral therapy; Environmental health; Syphilis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00121577,0.0006182347,0.001493503,0.0001947145,0.0001999843,0.0004412685,0.0004717858,0.0007292361,0.002566834],"category_scores_gemma":[0.001176381,0.000202221,0.001509751,0.0002039451,0.0002841357,0.0004181285,0.0002278084,0.0013475,0.0002202182],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003602106,"about_ca_system_score_gemma":0.0003283688,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001268505,"about_ca_topic_score_gemma":0.003160951,"domain_scores_codex":[0.9994425,0.0003541746,0.00004368381,0.00004938255,0.00004570085,0.00006440478],"domain_scores_gemma":[0.9992932,0.0002366587,0.0001970745,0.00006590263,0.00006465212,0.0001425116],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8794079,0.007576755,0.01012211,0.003137532,0.005634662,0.0001033284,0.0001040952,0.0006531139,0.006976859,0.0001348601,0.001035541,0.08511311],"study_design_scores_gemma":[0.4937774,0.380593,0.1062412,0.0005685968,0.00929707,0.0003566967,0.0001479713,0.001152745,0.004301376,0.0002101354,0.003309678,0.0000440084],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880713,0.008918238,0.0001010145,0.0001700695,0.0001324673,0.0004192861,0.0005145736,0.00001767798,0.001655338],"genre_scores_gemma":[0.995908,0.002486422,0.0001796929,0.000138979,0.0001797372,0.0002088471,0.0003925411,0.000003588485,0.0005021598],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002566834,"threshold_uncertainty_score":0.008586943,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007180520103017419,"score_gpt":0.2835234210325159,"score_spread":0.2763429009294985,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}