{"id":"W2900063234","doi":"10.1186/s13223-018-0305-2","title":"Unraveling the enigma: elucidating the relationship between the physicochemical properties of aluminium-based adjuvants and their immunological mechanisms of action","year":2018,"lang":"en","type":"review","venue":"Allergy Asthma and Clinical Immunology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Adjuvant; Aluminium; Vaccine adjuvant; Cytotoxicity; Chemistry; Immunology; Biology; Biochemistry; In vitro; Organic chemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.002374899,0.0004686614,0.001614552,0.00009345286,0.0006465024,0.00002371323,0.0007781566,0.001347364,0.00004424967],"category_scores_gemma":[0.001950811,0.0001981419,0.0005590628,0.0002303861,0.003733251,0.0000821665,0.000473742,0.001679544,0.00003062801],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002196471,"about_ca_system_score_gemma":0.0002276785,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005134741,"about_ca_topic_score_gemma":0.000008680405,"domain_scores_codex":[0.9934264,0.0037541,0.001870024,0.0004857294,0.00007159456,0.0003920924],"domain_scores_gemma":[0.9880949,0.009357289,0.001534292,0.0008228658,0.0001750294,0.00001564434],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008822142,0.0002333805,0.0001131799,0.0008163649,0.005156708,8.200784e-7,0.0007769703,5.784821e-7,0.02154102,0.00684033,0.0000904986,0.9635479],"study_design_scores_gemma":[0.005502358,0.005054596,0.02345003,0.01205717,0.002847337,0.0004488585,0.006566178,0.00007399745,0.1390969,0.006445287,0.796575,0.001882239],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.08237436,0.9153419,0.0005068664,0.0004521896,0.0005476808,0.0006891176,0.00001634517,0.00003012737,0.00004141553],"genre_scores_gemma":[0.4327524,0.5667927,0.00002347859,0.00004386882,0.000107846,0.00007179986,0.00009931323,0.00002733943,0.00008122894],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9616657,"threshold_uncertainty_score":0.9999491,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1210139976296258,"score_gpt":0.3437274674330694,"score_spread":0.2227134698034436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}